2025
The Dyson equalizer: adaptive noise stabilization for low-rank signal detection and recovery
Landa B, Kluger Y. The Dyson equalizer: adaptive noise stabilization for low-rank signal detection and recovery. Information And Inference A Journal Of The IMA 2025, 14: iaae036. PMID: 39830802, PMCID: PMC11735832, DOI: 10.1093/imaiai/iaae036.Peer-Reviewed Original ResearchNoise varianceLow-rank signalData matrixNoisy data matrixSignal detectionImproved signal recoverySignal recoveryMP lawNoise distributionRandom matrix theory resultsSignal structureData-drivenSingular valuesNoiseDataTaskNoise characteristicsNoise levelNoise stabilitySingle-cell RNA sequencingDetectionSpatial transcriptomics dataTranscriptome dataNormalization procedureMatrix
2022
Comprehensive visualization of cell–cell interactions in single-cell and spatial transcriptomics with NICHES
Raredon M, Yang J, Kothapalli N, Lewis W, Kaminski N, Niklason L, Kluger Y. Comprehensive visualization of cell–cell interactions in single-cell and spatial transcriptomics with NICHES. Bioinformatics 2022, 39: btac775. PMID: 36458905, PMCID: PMC9825783, DOI: 10.1093/bioinformatics/btac775.Peer-Reviewed Original ResearchConceptsCell-cell interactionsCell-cell signalingSingle-cell resolutionSingle-cell dataLocal cellular microenvironmentSingle-cell levelSpatial transcriptomics dataCell clustersExtracellular signalingTranscriptomic dataGene expression valuesSpatial transcriptomicsSignaling mechanismCellular microenvironmentNicheExpression valuesSupplementary dataSignalingTranscriptomicsComprehensive visualizationBioinformaticsInteraction
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