Structure and analysis of nanobody binding to the human ASIC1a ion channel
Wu Y, Chen Z, Sigworth FJ, Canessa CM. Structure and analysis of nanobody binding to the human ASIC1a ion channel. ELife 2021, 10: e67115. PMID: 34319232, PMCID: PMC8318589, DOI: 10.7554/elife.67115.Peer-Reviewed Original ResearchMeSH KeywordsAcid Sensing Ion ChannelsAnimalsCamelids, New WorldCryoelectron MicroscopyProtein BindingSingle-Domain AntibodiesConceptsIschemia-induced neuronal injuryModulation of painCoral snake bitesNeuronal injuryMambalgin-1ASIC1a channelsSnake bitePsalmotoxin-1Alpaca-derived nanobodySodium channelsPotential antidoteChannel activationASIC1aIon channelsPcTx1Snake toxinsTherapeutic applicationsHuman ASIC1aCryo-electron microscopyToxinHASIC1aPainInjuryC1-binding siteMolecular tools