Yangyu Wu
Postdoctoral AssociateAbout
Research
Publications
2021
Structure and analysis of nanobody binding to the human ASIC1a ion channel
Wu Y, Chen Z, Sigworth FJ, Canessa CM. Structure and analysis of nanobody binding to the human ASIC1a ion channel. ELife 2021, 10: e67115. PMID: 34319232, PMCID: PMC8318589, DOI: 10.7554/elife.67115.Peer-Reviewed Original ResearchConceptsIschemia-induced neuronal injuryModulation of painCoral snake bitesNeuronal injuryMambalgin-1ASIC1a channelsSnake bitePsalmotoxin-1Alpaca-derived nanobodySodium channelsPotential antidoteChannel activationASIC1aIon channelsPcTx1Snake toxinsTherapeutic applicationsHuman ASIC1aCryo-electron microscopyToxinHASIC1aPainInjuryC1-binding siteMolecular tools
2019
A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels
Wu Y, Chen Z, Canessa CM. A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels. ELife 2019, 8: e45851. PMID: 31045491, PMCID: PMC6497441, DOI: 10.7554/elife.45851.Peer-Reviewed Original ResearchA Mechanism for Desensitization of all Three Functional Mammalian Acid Sensing Ion Channels
Wu Y, Chen Z, Canessa C. A Mechanism for Desensitization of all Three Functional Mammalian Acid Sensing Ion Channels. Biophysical Journal 2019, 116: 36a. DOI: 10.1016/j.bpj.2018.11.237.Peer-Reviewed Original Research