2025
SORL1-Mediated EGFR and FGFR4 Regulation Enhances Chemoresistance in Ovarian Cancer
Jiang Z, Bi F, Ge Z, Mansolf M, Hartwich T, Kolesnyk V, Yang K, Park W, Kim D, Grechukhina O, Hui P, Kim S, Yang-Hartwich Y. SORL1-Mediated EGFR and FGFR4 Regulation Enhances Chemoresistance in Ovarian Cancer. Cancers 2025, 17: 244. PMID: 39858026, PMCID: PMC11763764, DOI: 10.3390/cancers17020244.Peer-Reviewed Original ResearchEpidermal growth factor receptorOvarian cancerRecurrent tumorsSortilin-related receptor 1Therapeutic efficacy of carboplatinResistant to conventional chemotherapyResistant ovarian cancerMolecular mechanisms of chemoresistanceCancer models in vitroEfficacy of carboplatinRecurrent ovarian cancerOvarian cancer treatmentEffective targeted therapiesMechanisms of chemoresistancePro-tumor functionsGrowth factor receptorXenograft mouse modelConventional chemotherapyStabilization of epidermal growth factor receptorModel in vitroPro-tumorEnhanced chemoresistanceCarboplatin resistanceTherapeutic efficacyFactor receptor
2007
Combined effect of total alkaloids from Feculae Bombycis and natural flavonoids on diabetes
Geng P, Yang Y, Gao Z, Yu Y, Shi Q, Bai G. Combined effect of total alkaloids from Feculae Bombycis and natural flavonoids on diabetes. Journal Of Pharmacy And Pharmacology 2007, 59: 1145-1150. PMID: 17725858, DOI: 10.1211/jpp.59.8.0013.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAlkaloidsAnimalsBlood GlucoseBombyxCholesterolDiabetes Mellitus, ExperimentalDrug SynergismDrug Therapy, CombinationFemaleFlavonoidsGlycoside Hydrolase InhibitorsIntestinal MucosaMaleMedicine, Chinese TraditionalMicePlant ExtractsPlants, MedicinalPostprandial PeriodRatsRats, WistarStarchConceptsInhibiting alpha-glucosidase activityAlpha-glucosidase activityDiabetic mice in vivoMice in vivoBlood glucoseStarch hydrolysateFlavonoidsFasting blood total cholesterolGlucose levelsIn vivoIndividual ingredientsBlood total cholesterolFasting blood glucoseDepressed blood glucose levelsNatural flavonoidPostprandial elevationBlood glucose levelsModel in vitroTherapy of diabetesTAFBShort-term studiesTotal cholesterolOral administrationBombycisBlood
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