2025
Hypercholesterolemia-induced LXR signaling in smooth muscle cells contributes to vascular lesion remodeling and visceral function
Zhang H, de Urturi D, Fernández-Tussy P, Huang Y, Jovin D, Zhang X, Huang S, Lek M, da Silva Catarino J, Sternak M, Citrin K, Swirski F, Gustafsson J, Greif D, Esplugues E, Biwer L, Suárez Y, Fernández-Hernando C. Hypercholesterolemia-induced LXR signaling in smooth muscle cells contributes to vascular lesion remodeling and visceral function. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2417512122. PMID: 40035761, PMCID: PMC11912459, DOI: 10.1073/pnas.2417512122.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsLiver X receptorLesion remodelingMuscle cellsVascular functionArterial media layerContribution of lipid metabolismPhenotypic switchingRegulate vascular toneMonocyte-derived macrophagesLipid metabolismPhenotypic switching of vascular smooth muscle cellsSwitching of vascular smooth muscle cellsNecrotic core areaRegulate vascular functionFoam cell populationVisceral myopathyBladder remodelingAortic atheromaFibrous cap thicknessRemodeling in vivoLipid malabsorptionVascular toneAbundant cell type
2015
Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease.
Araldi E, Chamorro-Jorganes A, van Solingen C, Fernandez-Hernando C, Suarez Y. Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease. Current Vascular Pharmacology 2015, 13: 291-304. PMID: 26156264, DOI: 10.2174/15701611113119990012.Peer-Reviewed Original ResearchConceptsPost-transcriptional levelMonocyte-derived phagocytesFoam cell formationGene regulatorsCell adhesion moleculeModulating microRNAsVascular smooth muscle cellsCell differentiationArterial tree resultsVascular diseaseCell formationMicroRNAsSmooth muscle cellsCap formationVascular cellsFibrous cap formationPotential therapeutic applicationsUnstable fibrous capUnstable coronary syndromesAtherosclerotic vascular diseaseTree resultsMuscle cellsChronic inflammatory diseaseProgression of atherosclerosisLesion-prone sites
2013
Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease.
Araldi E, Chamorro-Jorganes A, van Solingen C, Fernández-Hernando C, Suárez Y. Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease. Current Vascular Pharmacology 2013 PMID: 23713860, PMCID: PMC3883893.Peer-Reviewed Original ResearchPost-transcriptional levelMonocyte-derived phagocytesFoam cell formationGene regulatorsCell adhesion moleculeModulating microRNAsVascular smooth muscle cellsCell differentiationArterial tree resultsVascular diseaseCell formationMicroRNAsSmooth muscle cellsCap formationVascular cellsFibrous cap formationPotential therapeutic applicationsUnstable fibrous capUnstable coronary syndromesAtherosclerotic vascular diseaseTree resultsMuscle cellsChronic inflammatory diseaseProgression of atherosclerosisLesion-prone sites
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