2025
Medications for opioid use disorder shape immune responses during chronic HIV infection
Collora J, Steinhauser S, Davenport T, Lin D, Eshetu A, Zeidi S, Kim R, Frank C, Kluger Y, Springer S, Ho Y. Medications for opioid use disorder shape immune responses during chronic HIV infection. Cell Reports Medicine 2025, 6: 102159. PMID: 40460829, PMCID: PMC12208330, DOI: 10.1016/j.xcrm.2025.102159.Peer-Reviewed Original ResearchConceptsOpioid use disorderTumor necrosis factorImmune responseHIV infectionAssociated with HIV replicationCytotoxic T cell populationsRisk of opioid use disorderUse disorderPeripheral blood immune cellsI interferonChronic HIV infectionRNA expressionPartial agonist buprenorphineT cell populationsShape immune responsesBlood immune cellsType I interferonImprove immune responsesAgonist buprenorphineAgonist methadoneHIV expressionAntagonist naltrexoneHIV replicationImmune profileImmune cells
2022
Interferon opens up: HIV-induced inflammation reconfigures 3D chromatin conformation and affects where HIV integrates
Wei Y, Ho Y. Interferon opens up: HIV-induced inflammation reconfigures 3D chromatin conformation and affects where HIV integrates. Molecular Cell 2022, 82: 4585-4587. PMID: 36525953, PMCID: PMC9925257, DOI: 10.1016/j.molcel.2022.11.013.Peer-Reviewed Original Research
2009
Disseminated Cryptococcus neoformans var. grubii infections in intensive care units
CHUANG Y, KU SC, LIAW SJ, WU SC, HO YC, YU CJ, HSUEH PR. Disseminated Cryptococcus neoformans var. grubii infections in intensive care units. Epidemiology And Infection 2009, 138: 1036-1043. PMID: 19796452, DOI: 10.1017/s0950268809990926.Peer-Reviewed Original ResearchConceptsIntensive care unitICU admissionHIV infectionCare unitMortality rateChronic Health Evaluation II scoreLower white blood cell countGood long-term prognosisMultivariate Cox regression modelWhite blood cell countICU mortality rateMean Acute PhysiologicFrequent underlying diseasesLong-term prognosisCox regression modelBlood cell countSite of infectionCryptococcus neoformans varAcute PhysiologicICU stayCryptococcal infectionICU survivalII scoreClinical characteristicsUnderlying disease
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