2024
Clinicopathologic features and prognosis of steatohepatitic hepatocellular carcinoma based on varying cutoffs of tumoral steatohepatitic changes
Zhang T, Niu N, Taddei T, Jain D, Zhang X. Clinicopathologic features and prognosis of steatohepatitic hepatocellular carcinoma based on varying cutoffs of tumoral steatohepatitic changes. American Journal Of Clinical Pathology 2024, 163: 411-418. PMID: 39418121, DOI: 10.1093/ajcp/aqae136.Peer-Reviewed Original ResearchSH-HCCSteatohepatitic hepatocellular carcinomaHepatocellular carcinomaLiver diseaseHepatitis C virus infectionC virus infectionStage of fibrosisPresence of steatohepatitisOverall survivalHistological subtypesPrognostic factorsHCC subtypesBackground liverHCC casesClinicopathological featuresConventional HCCHistopathological patternsHyaline globulesTumor cellsMallory-Denk bodiesGlycogenated nucleiSteatotic liver diseaseHCCSurvival analysisSteatohepatitis
2023
Clinicopathologic characterization of hepatocellular adenomas in men: a multicenter experience
González I, Torbenson M, Sharifai N, Byrnes K, Chatterjee D, Kakar S, Yeh M, Wu T, Zhang X, Jain D. Clinicopathologic characterization of hepatocellular adenomas in men: a multicenter experience. Human Pathology 2023, 138: 24-33. PMID: 37245629, DOI: 10.1016/j.humpath.2023.05.010.Peer-Reviewed Original ResearchConceptsHepatocellular adenomaHepatocellular carcinomaMalignant transformationMulticenter experienceMean ageWorld Health Organization classificationConcomitant hepatocellular carcinomaAndrogen receptor expressionBenign liver neoplasmUnclassified hepatocellular adenomaUncertain malignant potentialInflammatory hepatocellular adenomaΒ-catenin-activated hepatocellular adenomaClinicopathologic characterizationEntire cohortHCA casesCommon subtypeMalignant potentialOrganization classificationReproductive ageAllred score systemResection casesReceptor expressionHepatocellular neoplasmsLiver neoplasms
2022
The many faces and pathologic diagnostic challenges of autoimmune hepatitis
Zhang X, Jain D. The many faces and pathologic diagnostic challenges of autoimmune hepatitis. Human Pathology 2022, 132: 114-125. PMID: 35753409, DOI: 10.1016/j.humpath.2022.06.019.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisHistological featuresLiver diseaseAcute-onset autoimmune hepatitisDiagnosis of AIHEnd-stage liver diseaseChronic inflammatory liver diseasePathologic diagnostic challengeFatal liver failureInflammatory liver diseaseTypical histological featuresCareful clinicopathological correlationRoutine clinical practiceMajor differential diagnosisImmunosuppressive treatmentLiver histologySpecific autoantibodiesLiver failurePrompt diagnosisHistological presentationClinicopathological correlationInternational Working GroupPathological featuresDiagnostic challengeHistopathologic spectrumProminent Pseudoacini in Focal Nodular Hyperplasia
Wang D, González IA, Russo PA, Jain D, Zhang X. Prominent Pseudoacini in Focal Nodular Hyperplasia. The American Journal Of Surgical Pathology 2022, 46: 1380-1385. PMID: 35749760, DOI: 10.1097/pas.0000000000001931.Peer-Reviewed Original ResearchConceptsFocal nodular hyperplasiaHepatocellular carcinomaNodular hyperplasiaFNH casesPotential diagnostic pitfallInspissated bileChronic cholestasisInitial biopsyPathologic featuresClinicopathologic correlationDiagnostic challengeNeedle biopsyDifferential diagnosisHepatocellular neoplasmsHepatocellular adenomaDiagnostic pitfallsMorphologic featuresLobular parenchymaStaining patternPseudoaciniBiliary transdifferentiationBiopsyHyperplasiaLesionsHepatocytesAn Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center.
Wang JD, Sebastian C, Walther Z, Suresh T, Lacy J, Zhang X, Jain D. An Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center. Archives Of Pathology & Laboratory Medicine 2022, 147: 185-192. PMID: 35512224, DOI: 10.5858/arpa.2021-0457-oa.Peer-Reviewed Original ResearchConceptsLiver biopsyUnknown primaryIHC markersPrimary siteTrue carcinomaTertiary care medical centerAvailable clinicopathologic dataSquamous cell carcinomaClinicopathologic dataHepatic metastasesNonepithelial tumorsCell carcinomaInstitutional databaseClinical managementStain usePractice patternsNeuroendocrine neoplasmsImmunohistochemical markersMedical CenterMorphologic patternsIndividualized approachCarcinomaBiopsyMetastasisTumors
2021
Pathogenic BRCA2 germline variants in combined hepatocellular‐cholangiocarcinoma
Li H, Zhang X, Finberg KE, Walther Z, Jain D, Gibson J. Pathogenic BRCA2 germline variants in combined hepatocellular‐cholangiocarcinoma. Pathology International 2021, 72: 138-140. PMID: 34808016, DOI: 10.1111/pin.13188.Peer-Reviewed Original ResearchHepatocellular Carcinoma
Jain A, Mazer B, Deng Y, Ciarleglio M, Jain D, Taddei T, Zhang X. Hepatocellular Carcinoma. American Journal Of Clinical Pathology 2021, 157: 305-313. PMID: 34542582, DOI: 10.1093/ajcp/aqab125.Peer-Reviewed Original ResearchConceptsAnaplastic tumor cellsHepatocellular carcinomaNoncirrhotic liverVascular invasionHistologic patternCirrhotic liverTumor cellsClear cell subtypePathogenesis of HCCHigh histologic gradeLarger tumor sizeHigher tumor stageHigh tumor gradeHigh rateHepatitis BHepatitis CLiver diseaseTumor sizeHistologic gradeTumor stageTumor gradePathologic differencesHCC casesRetrospective analysisPathology archivesClinicopathological significance of neutrophil-rich colorectal carcinoma
Rottmann BG, Patel N, Ahmed M, Deng Y, Ciarleglio M, Vyas M, Jain D, Zhang X. Clinicopathological significance of neutrophil-rich colorectal carcinoma. Journal Of Clinical Pathology 2021, 76: 34-39. PMID: 34312298, PMCID: PMC10910606, DOI: 10.1136/jclinpath-2021-207702.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalColorectal carcinomaHistological gradeTumor locationRight-sided tumor locationTumor cellsDNA mismatch repair (MMR) statusIndependent risk factorKaplan-Meier analysisHigh histological gradeAdvanced TNM stageMismatch repair statusPrognostic significanceCRC casesClinicopathological significanceTNM stageMetastasis stagePatient prognosisRisk factorsClinicopathological parametersMultivariate analysisRepair statusPatientsCarcinomaHigh rateHNF-1β is a More Sensitive and Specific Marker Than C-Reactive Protein for Identifying Biliary Differentiation in Primary Hepatic Carcinomas.
Patil PA, Taddei T, Jain D, Zhang X. HNF-1β is a More Sensitive and Specific Marker Than C-Reactive Protein for Identifying Biliary Differentiation in Primary Hepatic Carcinomas. Archives Of Pathology & Laboratory Medicine 2021, 146: 220-226. PMID: 34086854, DOI: 10.5858/arpa.2020-0725-oa.Peer-Reviewed Original ResearchCan primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis?
Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.Peer-Reviewed Original ResearchConceptsMetastatic hepatocellular carcinomaHepatocellular carcinomaHistologic patternHistomorphologic featuresPrimary tumorMetastatic tumorsMacrotrabecular-massive hepatocellular carcinomaCommon histologic patternPathogenesis of metastasisSignificant intratumoral heterogeneityExtrahepatic metastasesLymph nodesMicrovascular invasionAdrenal glandCommon subtypeNoncirrhotic liverCirrhotic liverCommon siteMetastatic tissuesLarge cohortAbdominal cavityHCC subtypesPathology archivesMetastasisHCC metastasisα-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study
Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHepatocytic lesionsDiagnosis of HCCLiver biopsy cohortHepatocyte paraffin 1Independent retrospective cohortsBenign liver lesionsMulti-center studyGood diagnostic valueNovel diagnostic biomarkersArginase-1 (Arg-1) proteinsΑ-fetoprotein mRNASurgical cohortRetrospective cohortBiopsy cohortHepPar-1Arg-1Liver lesionsDiagnostic biomarkersDiagnostic valueMalignancy lesionsLesionsGlypican3CohortSpecific markers
2020
Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy
Zhang X, Jain D. Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy. Annals Of The New York Academy Of Sciences 2020, 1482: 163-176. PMID: 32892349, DOI: 10.1111/nyas.14462.Peer-Reviewed Original ResearchConceptsNeoadjuvant therapyEsophageal cancerEsophageal carcinomaRecent American Joint CommitteePreoperative neoadjuvant therapyThorough pathologic assessmentTumor regression gradingAdvanced esophageal carcinomaAmerican Joint CommitteeCancer (AJCC) staging systemTumor regression gradeAccurate tumor stagingValuable prognostic informationRegression gradingSurgical resectionLymph nodesPathologic assessmentRegression gradeHistologic typePathologic evaluationResidual tumorPoor prognosisCell carcinomaGastrointestinal carcinomasStaging systemFibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation
Tefera J, Revzin M, Chapiro J, Savic L, Mulligan D, Batra R, Taddei T, Jain D, Zhang X. Fibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation. Journal Of Clinical Pathology 2020, 74: 31-35. PMID: 32430483, PMCID: PMC7674234, DOI: 10.1136/jclinpath-2020-206574.Peer-Reviewed Original ResearchConceptsAdvanced Barcelona Clinic Liver Cancer stageBarcelona Clinic Liver Cancer stageScirrhous HCCMultiple rounded nodulesNon-peripheral washoutLiver Cancer stageRadiological featuresClinical featuresRadiological correlationCarcinoma variantsCancer stageHCC casesHepatocellular carcinomaLiver cancerFibrotic liverConventional HCCHCCLower ratesHigh rateRounded nodulesProgressionDistinct patternsCarcinomaSpecific variantsLesionsMorphological spectrum of immune check‐point inhibitor therapy‐associated gastritis
Johncilla M, Grover S, Zhang X, Jain D, Srivastava A. Morphological spectrum of immune check‐point inhibitor therapy‐associated gastritis. Histopathology 2020, 76: 531-539. PMID: 31692018, DOI: 10.1111/his.14029.Peer-Reviewed Original ResearchConceptsImmune check-point inhibitor therapyCheck-point inhibitor therapyImmune-related adverse eventsImmune check point inhibitorsMorphological spectrumIntra-epithelial lymphocytosisCheck point inhibitorsChronic active gastritisInflammatory bowel diseaseMedical chart reviewCytotoxic T cellsDrug-induced gastritisPredominant histological patternDistribution of injuriesVariety of tumorsMechanism of actionSteroid therapyGastrointestinal injuryActive gastritisAdverse eventsChart reviewClinical suspicionMedication withdrawalBowel diseaseInhibitor therapy
2019
Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis
Patel N, Vyas M, Celli R, Jain D, Zhang X. Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis. The American Journal Of Surgical Pathology 2019, 44: 241-246. PMID: 31498179, DOI: 10.1097/pas.0000000000001369.Peer-Reviewed Original ResearchConceptsHigh-grade tumor buddingAdverse histologic featuresMalignant polypsNodal metastasisTumor buddingHistologic featuresLymphovascular invasionNode metastasisLymph node metastatic potentialMargin statusSubsequent resectionColectomy specimenColectomy proceduresDifferentiated clustersTumor differentiationOdds ratioRisk featuresMetastasisMetastatic potentialPiecemeal polypectomyPolypsRiskInvasionColectomyResectionPancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation
Beech C, Freedman-Weiss M, Salem R, Jain D, Zhang X. Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation. Gastroenterology Research 2019, 12: 185-190. PMID: 31523327, PMCID: PMC6731045, DOI: 10.14740/gr1201.Peer-Reviewed Original ResearchCarcinoembryonic antigen levelCEA levelsInvasive carcinomaAntigen levelsCEA stainingIntraductal papillary mucinous neoplasm subtypesPancreatic intraductal papillary mucinous neoplasmsIntraductal papillary mucinous neoplasmPresence of dysplasiaPapillary mucinous neoplasmGrade of dysplasiaRisk of malignancySize of lesionsDuct involvementPathologic variablesCystic lesionsIPMN casesMucinous neoplasmsMucinous secretionHistopathologic correlationNeoplasm subtypesCarcinomaGlycoprotein expressionSignificant correlationDysplasiaMacrotrabecular Hepatocellular Carcinoma
Jeon Y, Benedict M, Taddei T, Jain D, Zhang X. Macrotrabecular Hepatocellular Carcinoma. The American Journal Of Surgical Pathology 2019, 43: 943-948. PMID: 31135484, DOI: 10.1097/pas.0000000000001289.Peer-Reviewed Original ResearchMeSH KeywordsAgedalpha-FetoproteinsCarcinoma, HepatocellularDisease ProgressionFemaleHepatectomyHepatitis BHepatitis CHumansLiver CirrhosisLiver NeoplasmsLiver TransplantationMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingProgression-Free SurvivalRetrospective StudiesRisk FactorsTime FactorsTumor BurdenConceptsHepatocellular carcinomaHCC subtypesHigh alpha-fetoprotein levelsWorse recurrence-free survivalDistinct HCC subtypeHepatitis C infectionRecurrence-free survivalAlpha-fetoprotein levelsAnaplastic tumor cellsHigh histologic gradePoor overall survivalConventional hepatocellular carcinomaHigh recurrence rateHigher AJCC stageDetailed pathologic evaluationMacrotrabecular patternC infectionPrimary resectionHepatitis BOverall survivalPathologic evaluationAJCC stageClinicopathologic featuresHistologic subtypeRecurrence rateGlucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary Carcinoma
Vyas M, Patel N, Celli R, Wajapeyee N, Jain D, Zhang X. Glucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary Carcinoma. Gastroenterology Research 2019, 12: 128-134. PMID: 31236153, PMCID: PMC6575135, DOI: 10.14740/gr1145.Peer-Reviewed Original ResearchColorectal micropapillary carcinomaGlucose transporter 1Micropapillary carcinomaGlucose metabolic reprogrammingColorectal carcinomaGlandular componentMetabolic reprogrammingGlycogen metabolismFrequent lymphovascular invasionCancer cell growthMPC therapyLymphovascular invasionTumor cell survivalAggressive variantPoor outcomeCell cycle arrestColon cancer cellsKi-67Glycogen metabolizing enzymesMetabolizing enzymesCarcinomaTransporter 1Cell proliferation arrestHCT116 colon cancer cellsReal-time PCR analysisClinical utility of genomic analysis in adults with idiopathic liver disease
Hakim A, Zhang X, DeLisle A, Oral EA, Dykas D, Drzewiecki K, Assis DN, Silveira M, Batisti J, Jain D, Bale A, Mistry PK, Vilarinho S. Clinical utility of genomic analysis in adults with idiopathic liver disease. Journal Of Hepatology 2019, 70: 1214-1221. PMID: 31000363, PMCID: PMC6526061, DOI: 10.1016/j.jhep.2019.01.036.Peer-Reviewed Original ResearchConceptsIdiopathic liver diseaseUnexplained liver diseaseManagement of adultsWhole-exome sequencingLiver diseaseAdult patientsUnknown etiologyHeterozygous variantsUse of WESAmelioration of dyslipidemiaDaily insulin requirementLeptin replacement therapyUtility of WESChronic liver diseaseNon-alcoholic steatohepatitisAcademic health care centerHealth care centersHomozygous pathogenic variantUnrelated adult patientsNon-oncological diseasesDisease preventive measuresInsulin requirementsLean patientsDevastating complicationLiver aminotransferases
2017
Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same?
Zhang X, Zhu H, Yang X, Adsay VN, Jain D. Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same? Pathology - Research And Practice 2017, 213: 997-1001. PMID: 28599853, DOI: 10.1016/j.prp.2017.03.013.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaAcinar cell differentiationCystic dilatationCystic lesionsNon-neoplastic cystic lesionsCyst formationEtiology of obstructionCareful gross examinationBenign pancreatic cystic lesionsPancreatic ductal systemPancreatic neuroendocrine tumorsPancreatic cystic lesionsCell differentiationAcinar cell cystadenomaObstructive lesionsAcinar cell neoplasmsExact pathogenesisHistologic findingsSized cystsCystic dilationNeuroendocrine tumorsPancreatic ductDuctal adenocarcinomaCell neoplasmsMetaplastic phenomenon
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