2015
Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals
Gao XB, Hermes G. Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals. Frontiers In Systems Neuroscience 2015, 9: 142. PMID: 26539086, PMCID: PMC4612503, DOI: 10.3389/fnsys.2015.00142.Peer-Reviewed Original ResearchHypocretin systemNormal physiological functionPhysiological functionsNeural plasticityHypocretin-containing neuronsPF/LHSubstantial plastic changesCritical brain functionsPathological conditionsLong-term behavioral changesHypocretin neuronsLateral hypothalamusDaily functionNeuronal activityPlastic changesLong-term changesPlasticityMental health implicationsNeuronal systemsRecent evidenceBrain functionBehavioral functionsNeural activityHealth implicationsDaily fluctuations
2007
Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons
Rao Y, Liu ZW, Borok E, Rabenstein RL, Shanabrough M, Lu M, Picciotto MR, Horvath TL, Gao XB. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. Journal Of Clinical Investigation 2007, 117: 4022-4033. PMID: 18060037, PMCID: PMC2104495, DOI: 10.1172/jci32829.Peer-Reviewed Original ResearchConceptsHypocretin/orexin neuronsLong-term potentiationOrexin neuronsGlutamatergic synapsesSynaptic plasticitySleep lossExperience-dependent synaptic plasticityDopamine D1 receptorsChronic sleep lossSleep-wake regulationModafinil treatmentLateral hypothalamusD1 receptorsSimilar potentiationBrain slicesNeuronal activityNeuronal circuitryDopamine systemNervous systemSynaptic strengthNeuronsPathological conditionsGentle handlingMiceWakefulness