2001
GABA, Not Glutamate, a Primary Transmitter Driving Action Potentials in Developing Hypothalamic Neurons
Gao X, Van Den Pol A. GABA, Not Glutamate, a Primary Transmitter Driving Action Potentials in Developing Hypothalamic Neurons. Journal Of Neurophysiology 2001, 85: 425-434. PMID: 11152743, DOI: 10.1152/jn.2001.85.1.425.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineCells, CulturedChloridesExcitatory Amino Acid AntagonistsGABA-A Receptor AntagonistsGamma-Aminobutyric AcidGlutamic AcidGramicidinHypothalamusImmunohistochemistryIn Vitro TechniquesMiceNeuronsNeurotransmitter AgentsPatch-Clamp TechniquesReceptors, GlutamateSpinal CordConceptsHypothalamic neuronsReceptor antagonist bicucullinePrimary inhibitory neurotransmitterMouse hypothalamic neuronsPrimary excitatory transmitterAntagonist bicucullineExcitatory transmitterGABA circuitsGlutamate transmissionInhibitory neurotransmitterMature brainBrain slicesSynaptic releaseNeuronal activitySpike activityNeuronal connectionsSpike frequencyExtracellular recordingsAction potentialsAntagonist 2Brain developmentHebbian mechanismsIntracellular ClNeuronsGABA
1998
Glutamate Inhibits GABA Excitatory Activity in Developing Neurons
van den Pol A, Gao X, Patrylo P, Ghosh P, Obrietan K. Glutamate Inhibits GABA Excitatory Activity in Developing Neurons. Journal Of Neuroscience 1998, 18: 10749-10761. PMID: 9852609, PMCID: PMC6793361, DOI: 10.1523/jneurosci.18-24-10749.1998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCalciumCells, CulturedCerebral CortexEmbryo, MammalianExcitatory Postsynaptic PotentialsGABA AntagonistsGamma-Aminobutyric AcidGene ExpressionGlutamic AcidGramicidinHypothalamusIn Vitro TechniquesNeuronsPatch-Clamp TechniquesPresynaptic TerminalsPropionatesRatsRats, Sprague-DawleyReceptors, Metabotropic GlutamateSpinal CordConceptsGroup III mGluRsExcitatory actionGABA activityGroup II metabotropic glutamate receptorsFura-2 digital imagingSynapse formationBrain developmentInhibitory roleAgonist L-AP4Excitatory GABA actionsGlutamate-mediated inhibitionMetabotropic glutamate receptorsSpinal cord neuronsMajor inhibitory neurotransmitterWhole-cell recordingsSimilar inhibitory actionBrain GABAEarly brain developmentExcitatory roleGABA releaseL-AP4Excitatory transmitterGABA actionHypothalamic neuronsCord neurons