2015
Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation
Hu W, Jain A, Gao Y, Dozmorov I, Mandraju R, Wakeland E, Pasare C. Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 13994-13999. PMID: 26508631, PMCID: PMC4653191, DOI: 10.1073/pnas.1510760112.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportAnimalsBase SequenceBlotting, WesternCD4-Positive T-LymphocytesCell ProliferationDendritic CellsFlow CytometryGene Expression RegulationLipopolysaccharidesMiceMice, KnockoutMolecular Sequence DataSequence Analysis, RNASignal TransductionToll-Like Receptor 3Toll-Like Receptor 4ConceptsIFN regulatory factor 3Toll-like receptorsType I IFNIndependent of type I IFNsRecognition of pathogen-associated molecular patternsSignaling pathwayPathogen-associated molecular patternsI IFNTRIF-mediated signalingActivation of mitogen-activated protein kinasesMitogen-activated protein kinaseRegulatory factor 3IFN-BSignaling pathways of TLR4TRIF signaling pathwayType I IFN-dependentProtein kinaseMyeloid differentiation factorMolecular patternsMolecular mechanismsDC maturationUp-regulatedFactor 3Secretion of proinflammatory cytokinesTLR3-TRIF
2011
Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt
Troutman T, Hu W, Fulenchek S, Yamazaki T, Kurosaki T, Bazan J, Pasare C. Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 109: 273-278. PMID: 22187460, PMCID: PMC3252926, DOI: 10.1073/pnas.1118579109.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsB-LymphocytesEnzyme ActivationHEK293 CellsHumansInflammationMacrophagesMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataMyeloid Differentiation Factor 88Phosphatidylinositol 3-KinasesProtein Structure, TertiaryProto-Oncogene Proteins c-aktSignal TransductionToll-Like ReceptorsConceptsToll-IL-1 receptorToll-like receptorsB-cell adapterPI3KSignaling to activationSusceptibility to dextran sulfate sodium-induced colitisActivation of transcription factorsActivation of PI3KB cellsToll-IL-1 receptor domain-containing adapterRecruitment of inflammatory myeloid cellsToll-like receptor signalingPI3K activitySignal adaptationTLR signaling pathwaysIFN regulatory factorPrimary response geneToll-like receptor stimulationDextran sulfate sodium-induced colitisInflammatory myeloid cellsInduce activation of transcription factorsMyeloid differentiation primary response geneHomology domainDifferentiation primary response geneTranscription factors
2006
The Solution Structure of Escherichia coli Wzb Reveals a Novel Substrate Recognition Mechanism of Prokaryotic Low Molecular Weight Protein-tyrosine Phosphatases*
Lescop E, Hu Y, Xu H, Hu W, Chen J, Xia B, Jin C. The Solution Structure of Escherichia coli Wzb Reveals a Novel Substrate Recognition Mechanism of Prokaryotic Low Molecular Weight Protein-tyrosine Phosphatases*. Journal Of Biological Chemistry 2006, 281: 19570-19577. PMID: 16651264, DOI: 10.1074/jbc.m601263200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceEscherichia coliEscherichia coli ProteinsMagnetic Resonance SpectroscopyModels, MolecularMolecular Sequence DataMolecular WeightPhosphatesPhosphoprotein PhosphatasesPolysaccharidesProtein BindingProtein ConformationProtein Tyrosine PhosphatasesSequence Homology, Amino AcidSubstrate SpecificityConceptsSubstrate recognition mechanismLMW-PTPsLMW-PTPStructure-based multiple sequence alignmentLow molecular weight protein tyrosine phosphataseMolecular weight protein tyrosine phosphataseColanic acid productionMultiple sequence alignmentRecognition mechanismCatalytic mechanismProtein tyrosine phosphataseSolution structureSequence alignmentEscherichia coliPathogenic bacteriaAromatic amino acidsWzbMolecular basisAcid productionStructural basisBiological processesAmino acidsRational drug designActive siteDrug design
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