2015
Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation
Hu W, Jain A, Gao Y, Dozmorov I, Mandraju R, Wakeland E, Pasare C. Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 13994-13999. PMID: 26508631, PMCID: PMC4653191, DOI: 10.1073/pnas.1510760112.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportAnimalsBase SequenceBlotting, WesternCD4-Positive T-LymphocytesCell ProliferationDendritic CellsFlow CytometryGene Expression RegulationLipopolysaccharidesMiceMice, KnockoutMolecular Sequence DataSequence Analysis, RNASignal TransductionToll-Like Receptor 3Toll-Like Receptor 4ConceptsIFN regulatory factor 3Toll-like receptorsType I IFNIndependent of type I IFNsRecognition of pathogen-associated molecular patternsSignaling pathwayPathogen-associated molecular patternsI IFNTRIF-mediated signalingActivation of mitogen-activated protein kinasesMitogen-activated protein kinaseRegulatory factor 3IFN-BSignaling pathways of TLR4TRIF signaling pathwayType I IFN-dependentProtein kinaseMyeloid differentiation factorMolecular patternsMolecular mechanismsDC maturationUp-regulatedFactor 3Secretion of proinflammatory cytokinesTLR3-TRIF
2013
Location, location, location: tissue-specific regulation of immune responses
Hu W, Pasare C. Location, location, location: tissue-specific regulation of immune responses. Journal Of Leukocyte Biology 2013, 94: 409-421. PMID: 23825388, PMCID: PMC3747123, DOI: 10.1189/jlb.0413207.Peer-Reviewed Original ResearchConceptsImmune responseOutcome of adaptive immunityStromal cellsImmune systemOutcome of immune responsesInduction of innateAntigen-specific TAdaptive immune cellsAdaptive-immune responsesActivation of PRRRegulation of immune responsesSecretion of inflammatory cytokinesMucosal immune systemAdaptive immune responsesTissue-specific factorsImmune cellsInflammatory cytokinesReceptor activationAdaptive immunityTissue-specific regulationCommensal microbiotaPhenotypic heterogeneityImmune challengeInnateSignaling events
2011
Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment
Hu W, Troutman T, Edukulla R, Pasare C. Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment. Immunity 2011, 35: 1010-1022. PMID: 22137454, PMCID: PMC3246047, DOI: 10.1016/j.immuni.2011.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensAntigens, CDCell DifferentiationCell LineageCytokinesDendritic CellsIntegrin alpha ChainsInterleukin-6Lymphoid TissueMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMyeloid Differentiation Factor 88Receptors, Interleukin-1Signal TransductionTh17 CellsConceptsDendritic cellsInterleukin-6Cytokine requirementsCell lineage commitmentDifferentiation of CD4(+) T cellsLineage cellsCD4(+) T cellsActivation of pattern recognition receptorsTh17 lineage cellsTransforming growth factor-bCutaneous immune systemTh17 cell lineage commitmentLineage commitmentT helper 17Th17 cell polarizationSecretion of cytokinesTh17 cell primingGrowth factor BSite of primingTh17 cell differentiationIL-6-independentPattern recognition receptorsT-helperT cellsCell priming
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