Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment
Hu W, Troutman T, Edukulla R, Pasare C. Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment. Immunity 2011, 35: 1010-1022. PMID: 22137454, PMCID: PMC3246047, DOI: 10.1016/j.immuni.2011.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensAntigens, CDCell DifferentiationCell LineageCytokinesDendritic CellsIntegrin alpha ChainsInterleukin-6Lymphoid TissueMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMyeloid Differentiation Factor 88Receptors, Interleukin-1Signal TransductionTh17 CellsConceptsDendritic cellsInterleukin-6Cytokine requirementsCell lineage commitmentDifferentiation of CD4(+) T cellsLineage cellsCD4(+) T cellsActivation of pattern recognition receptorsTh17 lineage cellsTransforming growth factor-bCutaneous immune systemTh17 cell lineage commitmentLineage commitmentT helper 17Th17 cell polarizationSecretion of cytokinesTh17 cell primingGrowth factor BSite of primingTh17 cell differentiationIL-6-independentPattern recognition receptorsT-helperT cellsCell priming
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