2016
ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination
Akbar M, Mandraju R, Tracy C, Hu W, Pasare C, Krämer H. ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination. Immunity 2016, 45: 267-279. PMID: 27496733, PMCID: PMC4988897, DOI: 10.1016/j.immuni.2016.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArthrogryposisCells, CulturedCholestasisDrosophilaDrosophila ProteinsEndosomesEscherichia coli InfectionsGene Knockout TechniquesInflammationMacrophagesMiceProtein TransportRenal InsufficiencyRNA, Small InterferingSignal TransductionToll-Like Receptor 4Vesicular Transport ProteinsConceptsPattern recognition receptorsToll-like receptorsEndosomal maturationTrafficking of endosomesMaturation of phagosomesPattern recognition receptor activationSignaling endosomesMicrobial recognitionEndosomal compartmentsMicrobial ligandsSignal terminationEndosomesInitial signalVPS33BInflammatory responseProteinInduce inflammatory responsesExaggerated inflammatory responseExpression of inflammatory mediatorsDrosophilaReceptorsARC syndromeSignalPhagosomesMaturation
2015
Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation
Hu W, Jain A, Gao Y, Dozmorov I, Mandraju R, Wakeland E, Pasare C. Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 13994-13999. PMID: 26508631, PMCID: PMC4653191, DOI: 10.1073/pnas.1510760112.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportAnimalsBase SequenceBlotting, WesternCD4-Positive T-LymphocytesCell ProliferationDendritic CellsFlow CytometryGene Expression RegulationLipopolysaccharidesMiceMice, KnockoutMolecular Sequence DataSequence Analysis, RNASignal TransductionToll-Like Receptor 3Toll-Like Receptor 4ConceptsIFN regulatory factor 3Toll-like receptorsType I IFNIndependent of type I IFNsRecognition of pathogen-associated molecular patternsSignaling pathwayPathogen-associated molecular patternsI IFNTRIF-mediated signalingActivation of mitogen-activated protein kinasesMitogen-activated protein kinaseRegulatory factor 3IFN-BSignaling pathways of TLR4TRIF signaling pathwayType I IFN-dependentProtein kinaseMyeloid differentiation factorMolecular patternsMolecular mechanismsDC maturationUp-regulatedFactor 3Secretion of proinflammatory cytokinesTLR3-TRIF
2013
IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
Lin K, Hu W, Troutman T, Jennings M, Brewer T, Li X, Nanda S, Cohen P, Thomas J, Pasare C. IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 111: 775-780. PMID: 24379360, PMCID: PMC3896167, DOI: 10.1073/pnas.1320294111.Peer-Reviewed Original ResearchConceptsNucleotide-binding oligomerization domain-like receptorToll-like receptorsCaspase-1 activationLeucine-rich repeatCell death programAssembly of inflammasomesCaspase-1Cytosolic protein complexesIRAK-1IL-1 receptor-associated kinaseActivate caspase-1Receptor-associated kinaseCaspase-1 cleavageEarly host defenseDeath programOligomerization domain-like receptorVirulence factorsNucleotide bindingMicrobial recognitionStimulate Toll-like receptorsListeria monocytogenesProtein complexesPathogen infectionPro-IL-18Virulent microbes
2011
Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt
Troutman T, Hu W, Fulenchek S, Yamazaki T, Kurosaki T, Bazan J, Pasare C. Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 109: 273-278. PMID: 22187460, PMCID: PMC3252926, DOI: 10.1073/pnas.1118579109.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsB-LymphocytesEnzyme ActivationHEK293 CellsHumansInflammationMacrophagesMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataMyeloid Differentiation Factor 88Phosphatidylinositol 3-KinasesProtein Structure, TertiaryProto-Oncogene Proteins c-aktSignal TransductionToll-Like ReceptorsConceptsToll-IL-1 receptorToll-like receptorsB-cell adapterPI3KSignaling to activationSusceptibility to dextran sulfate sodium-induced colitisActivation of transcription factorsActivation of PI3KB cellsToll-IL-1 receptor domain-containing adapterRecruitment of inflammatory myeloid cellsToll-like receptor signalingPI3K activitySignal adaptationTLR signaling pathwaysIFN regulatory factorPrimary response geneToll-like receptor stimulationDextran sulfate sodium-induced colitisInflammatory myeloid cellsInduce activation of transcription factorsMyeloid differentiation primary response geneHomology domainDifferentiation primary response geneTranscription factors
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