2016
ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination
Akbar M, Mandraju R, Tracy C, Hu W, Pasare C, Krämer H. ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination. Immunity 2016, 45: 267-279. PMID: 27496733, PMCID: PMC4988897, DOI: 10.1016/j.immuni.2016.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArthrogryposisCells, CulturedCholestasisDrosophilaDrosophila ProteinsEndosomesEscherichia coli InfectionsGene Knockout TechniquesInflammationMacrophagesMiceProtein TransportRenal InsufficiencyRNA, Small InterferingSignal TransductionToll-Like Receptor 4Vesicular Transport ProteinsConceptsPattern recognition receptorsToll-like receptorsEndosomal maturationTrafficking of endosomesMaturation of phagosomesPattern recognition receptor activationSignaling endosomesMicrobial recognitionEndosomal compartmentsMicrobial ligandsSignal terminationEndosomesInitial signalVPS33BInflammatory responseProteinInduce inflammatory responsesExaggerated inflammatory responseExpression of inflammatory mediatorsDrosophilaReceptorsARC syndromeSignalPhagosomesMaturation
2012
T helper 17 cell lineage commitment is dictated by DC populations resident in priming tissues (163.23)
Hu W, Troutman T, Pasare C. T helper 17 cell lineage commitment is dictated by DC populations resident in priming tissues (163.23). The Journal Of Immunology 2012, 188: 163.23-163.23. DOI: 10.4049/jimmunol.188.supp.163.23.Peer-Reviewed Original ResearchCD103+ dendritic cellsDendritic cellsTh17 lineage commitmentIL-6IL-1Th17 differentiationLineage commitmentDifferentiation of CD4 T cellsGeneration of iTreg cellsTh17 cells in vitroActivation of pattern recognition receptorsDifferentiation of Th17 cells in vitroTh1 lineage developmentCD103+ DCCD4 T cellsContribution of IL-6Mucosal immune systemIntestinal immune homeostasisSecretion of cytokinesIntestinal lamina propriaSite of primingCells in vitroRegulate Th17 differentiationPattern recognition receptorsITreg cells
2011
Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment
Hu W, Troutman T, Edukulla R, Pasare C. Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment. Immunity 2011, 35: 1010-1022. PMID: 22137454, PMCID: PMC3246047, DOI: 10.1016/j.immuni.2011.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensAntigens, CDCell DifferentiationCell LineageCytokinesDendritic CellsIntegrin alpha ChainsInterleukin-6Lymphoid TissueMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMyeloid Differentiation Factor 88Receptors, Interleukin-1Signal TransductionTh17 CellsConceptsDendritic cellsInterleukin-6Cytokine requirementsCell lineage commitmentDifferentiation of CD4(+) T cellsLineage cellsCD4(+) T cellsActivation of pattern recognition receptorsTh17 lineage cellsTransforming growth factor-bCutaneous immune systemTh17 cell lineage commitmentLineage commitmentT helper 17Th17 cell polarizationSecretion of cytokinesTh17 cell primingGrowth factor BSite of primingTh17 cell differentiationIL-6-independentPattern recognition receptorsT-helperT cellsCell priming
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