2015
Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation
Hu W, Jain A, Gao Y, Dozmorov I, Mandraju R, Wakeland E, Pasare C. Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 13994-13999. PMID: 26508631, PMCID: PMC4653191, DOI: 10.1073/pnas.1510760112.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportAnimalsBase SequenceBlotting, WesternCD4-Positive T-LymphocytesCell ProliferationDendritic CellsFlow CytometryGene Expression RegulationLipopolysaccharidesMiceMice, KnockoutMolecular Sequence DataSequence Analysis, RNASignal TransductionToll-Like Receptor 3Toll-Like Receptor 4ConceptsIFN regulatory factor 3Toll-like receptorsType I IFNIndependent of type I IFNsRecognition of pathogen-associated molecular patternsSignaling pathwayPathogen-associated molecular patternsI IFNTRIF-mediated signalingActivation of mitogen-activated protein kinasesMitogen-activated protein kinaseRegulatory factor 3IFN-BSignaling pathways of TLR4TRIF signaling pathwayType I IFN-dependentProtein kinaseMyeloid differentiation factorMolecular patternsMolecular mechanismsDC maturationUp-regulatedFactor 3Secretion of proinflammatory cytokinesTLR3-TRIF
2006
Solution Structure and Backbone Dynamics of an Endopeptidase HycI from scherichia coli IMPLICATIONS FOR MECHANISM OF THE [NiFe] HYDROGENASE MATURATION*
Yang F, Hu W, Xu H, Li C, Xia B, Jin C. Solution Structure and Backbone Dynamics of an Endopeptidase HycI from scherichia coli IMPLICATIONS FOR MECHANISM OF THE [NiFe] HYDROGENASE MATURATION*. Journal Of Biological Chemistry 2006, 282: 3856-3863. PMID: 17150961, DOI: 10.1074/jbc.m609263200.Peer-Reviewed Original ResearchConceptsSolution structureMetal ion titration experimentsApo formBackbone dynamics studiesMolecular mechanisms of recognitionDynamics studiesMetabolism of hydrogenC-terminal cleavageHydrogenase 3Substrate recognitionCrystal structureFamily proteinsMechanism of recognitionTitration experimentsEscherichia coliBackbone dynamicsCleavage processClosed conformationHycIBiological functionsBiological processesMolecular mechanismsEndopeptidaseM52Cleavage
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