2016
ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination
Akbar M, Mandraju R, Tracy C, Hu W, Pasare C, Krämer H. ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination. Immunity 2016, 45: 267-279. PMID: 27496733, PMCID: PMC4988897, DOI: 10.1016/j.immuni.2016.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArthrogryposisCells, CulturedCholestasisDrosophilaDrosophila ProteinsEndosomesEscherichia coli InfectionsGene Knockout TechniquesInflammationMacrophagesMiceProtein TransportRenal InsufficiencyRNA, Small InterferingSignal TransductionToll-Like Receptor 4Vesicular Transport ProteinsConceptsPattern recognition receptorsToll-like receptorsEndosomal maturationTrafficking of endosomesMaturation of phagosomesPattern recognition receptor activationSignaling endosomesMicrobial recognitionEndosomal compartmentsMicrobial ligandsSignal terminationEndosomesInitial signalVPS33BInflammatory responseProteinInduce inflammatory responsesExaggerated inflammatory responseExpression of inflammatory mediatorsDrosophilaReceptorsARC syndromeSignalPhagosomesMaturation
2013
IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
Lin K, Hu W, Troutman T, Jennings M, Brewer T, Li X, Nanda S, Cohen P, Thomas J, Pasare C. IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 111: 775-780. PMID: 24379360, PMCID: PMC3896167, DOI: 10.1073/pnas.1320294111.Peer-Reviewed Original ResearchConceptsNucleotide-binding oligomerization domain-like receptorToll-like receptorsCaspase-1 activationLeucine-rich repeatCell death programAssembly of inflammasomesCaspase-1Cytosolic protein complexesIRAK-1IL-1 receptor-associated kinaseActivate caspase-1Receptor-associated kinaseCaspase-1 cleavageEarly host defenseDeath programOligomerization domain-like receptorVirulence factorsNucleotide bindingMicrobial recognitionStimulate Toll-like receptorsListeria monocytogenesProtein complexesPathogen infectionPro-IL-18Virulent microbes
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply