IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
Lin K, Hu W, Troutman T, Jennings M, Brewer T, Li X, Nanda S, Cohen P, Thomas J, Pasare C. IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 111: 775-780. PMID: 24379360, PMCID: PMC3896167, DOI: 10.1073/pnas.1320294111.Peer-Reviewed Original ResearchConceptsNucleotide-binding oligomerization domain-like receptorToll-like receptorsCaspase-1 activationLeucine-rich repeatCell death programAssembly of inflammasomesCaspase-1Cytosolic protein complexesIRAK-1IL-1 receptor-associated kinaseActivate caspase-1Receptor-associated kinaseCaspase-1 cleavageEarly host defenseDeath programOligomerization domain-like receptorVirulence factorsNucleotide bindingMicrobial recognitionStimulate Toll-like receptorsListeria monocytogenesProtein complexesPathogen infectionPro-IL-18Virulent microbes
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