The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation
Stacey J, HrebĂk D, Nand E, Shetty S, Qu K, Boicu M, Anders-Ă–sswein M, Uchil P, Dick R, Mothes W, Kräusslich H, MĂĽller B, Briggs J. The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation. Nature 2025, 1-7. PMID: 40011770, DOI: 10.1038/s41586-025-08624-9.Peer-Reviewed Original ResearchSpacer peptide 2Membrane-binding domainVirus particlesProtein-protein interfacesCleavage site mutantsHigh-resolution structuresFusion of virusImmature virus particlesHIV-1Site mutantsProteolytic cleavageFunctional domainsHuman immunodeficiency virus type 1Bound lipidsImmunodeficiency virus type 1Infectious virionsHIV-1 componentsStructural polyprotein GagMature latticeProtein latticeVirus type 1Structural maturationMonolayers in vitroPeptide 2Polyprotein Gag
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply