2023
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation
Arumugam S, Li B, Boodapati S, Nathanson M, Sun B, Ouyang X, Mehal W. Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation. Hepatology 2023, 78: 1448-1461. PMID: 37013923, PMCID: PMC10804318, DOI: 10.1097/hep.0000000000000388.Peer-Reviewed Original ResearchConceptsVoltage-dependent anion channelBioenergetic capacityMitochondrial DNATranscriptional upregulationCyclic GMP-AMP synthaseGMP-AMP synthaseTranscriptional regulationBioenergetic organellesFunctional mitochondriaMitochondrial membraneExternal mitochondrial membraneAnabolic pathwaysMitochondrial massAnion channelInterferon genesHSC transdifferentiationSubsequent activationCGAS-STINGTransdifferentiationIRF3 pathwayPathwaySTING pathwayGenesMitochondriaQuiescent HSCs
2019
Hematology Safety Data for the Fermented Soy Beverage Q-CAN® Plus (P12-033-19)
Mehal W, Suyavaran A, Dioletis E, Paiva R, Secor E, Weiss T, Fields M, Ouyang X, Ali A. Hematology Safety Data for the Fermented Soy Beverage Q-CAN® Plus (P12-033-19). Current Developments In Nutrition 2019, 3: 3013529. PMCID: PMC6574472, DOI: 10.1093/cdn/nzz035.p12-033-19.Peer-Reviewed Original ResearchObese individualsMean corpuscular hemoglobin concentrationMean corpuscular hemoglobinTreatment periodHematological parametersVisit 1Red blood cell distribution widthC-reactive proteinMethods Prospective studyCell distribution widthYale New Haven HealthCorpuscular hemoglobin concentrationVisit 7Clinic visitsProspective studyVisit 3Significant changesWBC countPlatelet volumeVisit 8Safety dataHematology labCorpuscular volumeHemoglobin concentrationBlood indicesReduction in Serum Levels of Inflammatory Cytokines in Subjects Consuming the Fermented Soy Beverage Q-CAN® Plus (P19-010-19)
Mehal W, Suyavaran A, Dioletis E, Paiva R, Weiss T, Fields M, Ouyang X. Reduction in Serum Levels of Inflammatory Cytokines in Subjects Consuming the Fermented Soy Beverage Q-CAN® Plus (P19-010-19). Current Developments In Nutrition 2019, 3: nzz049.p19-010-19. PMCID: PMC6579392, DOI: 10.1093/cdn/nzz049.p19-010-19.Peer-Reviewed Original ResearchObese subjectsSerum levelsInflammatory cytokinesIL-1raVisit 1Obese individualsHuman magnetic LuminexPDGF-AA levelsMethods Prospective studyKey inflammatory cytokinesAB/BBConclusion ConsumptionGMCSF levelsMagnetic LuminexVisit 7Clinic visitsCytokine levelsLean subjectsProspective studyVisit 3Visit 8Healthy subjectsMetabolic disordersTherapeutic phasePDGF-AA
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