US mortality trends from alcohol‐associated hepatitis by sex, age, race, and ethnicity, 1999–2020
Banini B, Chauhan S, Amatya A, Dashti F, Zahrawi K, Zahrawi F, Mehal W, McKee S. US mortality trends from alcohol‐associated hepatitis by sex, age, race, and ethnicity, 1999–2020. Alcohol Clinical And Experimental Research 2024, 49: 358-367. PMID: 39739407, DOI: 10.1111/acer.15515.Peer-Reviewed Original ResearchAmerican Indians/Alaska NativesMortality rate ratiosIndians/Alaska NativesCenters for Disease Control and Prevention Wide-ranging Online DataUS Centers for Disease Control and Prevention Wide-ranging ONline DataWide-ranging Online DataMortality rateUS mortality trendsAlcohol-associated hepatitisJoinpoint regression analysisYoung adultsCross-sectional studyAlcohol-associated liver diseaseYoung adult femalesHigh-risk populationOnline DataMortality trendsSteepest increaseUnited StatesYear compared to baselineCalendar trendsSociodemographic factorsRacial/ethnic groupsEpidemiological researchRate ratiosComplement protein signatures in patients with alcohol-associated hepatitis
Taiwo M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, Streem D, McClain C, Mitchell M, Barton B, Szabo G, Dasarathy S, Consortium A, Schaefer E, Luther J, Day L, Ouyang X, Suyavaran A, Mehal W, Jacobs J, Goodman R, Rotroff D, Nagy L. Complement protein signatures in patients with alcohol-associated hepatitis. JCI Insight 2024, 9: e174127. PMID: 38573776, PMCID: PMC11141929, DOI: 10.1172/jci.insight.174127.Peer-Reviewed Original ResearchAlcohol-associated hepatitisSevere AHAlcohol use disorderAlcoholic cirrhosisHealthy controlsPredicting 90-day mortalityComplement proteinsSerum proteome of patientsEthanol-induced liver injurySerum proteomeDevelopment of effective therapiesProteome of patientsAssociated with pro-inflammatory cytokinesProtein signaturesPro-inflammatory cytokinesCoagulation factors IINon-invasive biomarkersDiagnostic challengeSerine protease 1Murine modelEffective therapyLiver injuryPrognostic biomarkerHepatic inflammationC1q binding protein
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