2025
Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018
Sanchez-Pinto L, Daniels L, Atreya M, Faustino E, Farris R, Geva A, Khemani R, Rogerson C, Shah S, Weiss S, Bennett T. Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018. Pediatric Critical Care Medicine 2025, 26: e155-e165. PMID: 39982153, PMCID: PMC11792981, DOI: 10.1097/pcc.0000000000003675.Peer-Reviewed Original ResearchConceptsInternational Pediatric Sepsis Consensus ConferenceInternational Pediatric Sepsis Consensus Conference criteriaPhoenix criteriaCritically ill childrenSepsis criteriaPICU admissionCohort of critically ill childrenOrgan dysfunction scoreIll childrenMulticenter cohort studyHigher risk of mortalityMortality of patientsAge groupsIn-hospital mortalityRisk of mortalitySeverity of illnessDiscrimination of mortalityBloodstream infectionsSuspected infectionMulticenter cohortSeptic shockSepsis scoreDysfunction scorePatient subgroupsRetrospective analysis
2023
Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*
Sanchez-Pinto L, Bennett T, Stroup E, Luo Y, Atreya M, Bubeck Wardenburg J, Chong G, Geva A, Faustino E, Farris R, Hall M, Rogerson C, Shah S, Weiss S, Khemani R. Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*. Pediatric Critical Care Medicine 2023, 24: 795-806. PMID: 37272946, PMCID: PMC10540758, DOI: 10.1097/pcc.0000000000003292.Peer-Reviewed Original ResearchMultiple organ dysfunction syndromeSepsis-associated multiple organ dysfunction syndromePersistent hypoxemiaAdjuvant therapySepsis phenotypesSevere pediatric acute respiratory distress syndromePediatric acute respiratory distress syndromeMulticenter observational cohort studyAcute respiratory distress syndromePropensity score-matched analysisCommon adjuvant therapyHeterogeneity of sepsisOrgan dysfunction syndromeObservational cohort studyRespiratory distress syndromeHospital mortalityCohort studyDysfunction syndromeSystemic inflammationDistress syndromeOrgan dysfunctionSeptic shockClinical syndromeCommon therapyClinical relevance
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