2024
Multimodal predictive modeling: Scalable imaging informed approaches to predict future brain health
Ajith M, Spence J, Chapman S, Calhoun V. Multimodal predictive modeling: Scalable imaging informed approaches to predict future brain health. Journal Of Neuroscience Methods 2024, 414: 110322. PMID: 39608579, PMCID: PMC11687617, DOI: 10.1016/j.jneumeth.2024.110322.Peer-Reviewed Original ResearchStatic functional network connectivityHealth constructsNeuroimaging dataBrain healthResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingSupport vector regressionFunctional network connectivityRandom forestCognitive performanceAssessment-onlyRs-fMRINeural patternsBehavioral outcomesBehavioral dataDiverse data sourcesNeural connectionsPsychological stateTraining stageMagnetic resonance imagingLongitudinal changesNetwork connectivityBrainPerformance evaluationVector regressionAdolescent brain maturation associated with environmental factors: a multivariate analysis
Ray B, Jensen D, Suresh P, Thapaliya B, Sapkota R, Farahdel B, Fu Z, Chen J, Calhoun V, Liu J. Adolescent brain maturation associated with environmental factors: a multivariate analysis. Frontiers In Neuroimaging 2024, 3: 1390409. PMID: 39629197, PMCID: PMC11613425, DOI: 10.3389/fnimg.2024.1390409.Peer-Reviewed Original ResearchLeft medial orbitofrontal cortexReduced gray matter densityMedial orbitofrontal cortexMiddle temporal gyrusGray matter densityIncreased functional connectivityIncrease cognitive performanceSusceptible to environmental influencesBilateral occipital regionsDelayed brain maturationIncreased cortical thicknessOrbitofrontal cortexAdolescent brainHuman adolescentsTemporal gyrusBrain characteristicsCognitive performanceBrain regionsBrain age estimationBrain metricsFunctional connectivityBrain agingBrain maturationBrain variationBrain modalitiesA Method for Multimodal IVA Fusion Within a MISA Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies
Silva R, Damaraju E, Li X, Kochunov P, Ford J, Mathalon D, Turner J, van Erp T, Adali T, Calhoun V. A Method for Multimodal IVA Fusion Within a MISA Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies. Human Brain Mapping 2024, 45: e70037. PMID: 39560198, PMCID: PMC11574741, DOI: 10.1002/hbm.70037.Peer-Reviewed Original ResearchConceptsMultimodal neuroimaging datasetSchizophrenia patientsNeuroimaging studiesCognitive performanceGroup differencesSchizophreniaSex effectsNeuroimaging datasetsMagnetic resonance imagingCognitionAge-associated declineControl subjectsMarkers of agingResonance imagingNon-imaging variablesSubject profilesSexNeuroimagingUK Biobank datasetFunctional imaging derived ADHD biotypes based on deep clustering: a study on personalized medication therapy guidance
Feng A, Zhi D, Feng Y, Jiang R, Fu Z, Xu M, Zhao M, Yu S, Stevens M, Sun L, Calhoun V, Sui J. Functional imaging derived ADHD biotypes based on deep clustering: a study on personalized medication therapy guidance. EClinicalMedicine 2024, 77: 102876. PMID: 39763511, PMCID: PMC11701483, DOI: 10.1016/j.eclinm.2024.102876.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderAttention deficit hyperactivity disorder patientsFunctional network connectivityAttention Deficit Hyperactivity Disorder AdolescentTreatment of attention deficit hyperactivity disorderPeking University Sixth HospitalBackground Attention deficit hyperactivity disorderDeficit hyperactivity disorderTreated with methylphenidateADHD subtypesHyperactivity/impulsivity symptomsAdolescent brainMedical treatment effectsHyperactivity disorderCognitive performanceABCD studyProblem scoresNeuroimaging markersNeurodevelopmental disordersMedical treatmentChildhood onsetChina Postdoctoral Science FoundationNational Natural Science Foundation of ChinaNatural Science Foundation of ChinaPrimary medicationCognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population
Fu Z, Sui J, Iraji A, Liu J, Calhoun V. Cognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population. Molecular Psychiatry 2024, 30: 402-413. PMID: 39085394, PMCID: PMC11746149, DOI: 10.1038/s41380-024-02683-6.Peer-Reviewed Original ResearchDynamic functional connectivity statesDynamic functional connectivityAdolescent Brain Cognitive DevelopmentCognitive performanceDynamic functional connectivity patternsSensory networksAnalysis of dynamic functional connectivityFunctional connectivity statesDefault-modeNeurological underpinningsAttention problemsPsychiatric relevanceFunctional connectivitySensorimotor networkMediation analysisCognitive developmentChild's brainBrain statesMental healthMental problemsBrain dynamicsSliding-window approachMental behaviorBrainCerebellum4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia
Pusuluri K, Fu Z, Miller R, Pearlson G, Kochunov P, Van Erp T, Iraji A, Calhoun V. 4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia. Human Brain Mapping 2024, 45: e26773. PMID: 39045900, PMCID: PMC11267451, DOI: 10.1002/hbm.26773.Peer-Reviewed Original ResearchConceptsBrain networksFunctional magnetic resonance imagingAssociated with cognitive performanceDynamics of functional brain networksAssociated with cognitionFunctional brain networksVoxel-wise changesVolumetric couplingDynamical variablesCognitive performanceTypical controlsSchizophreniaCognitive impairmentNetwork pairsMagnetic resonance imagingPair of networksCognitionAtypical variabilityResonance imagingCouplingNetwork connectivityNetwork growthImpairmentBrainStatic networksA Dynamic Entropy Approach Reveals Reduced Functional Network Connectivity Trajectory Complexity in Schizophrenia
Blair D, Miller R, Calhoun V. A Dynamic Entropy Approach Reveals Reduced Functional Network Connectivity Trajectory Complexity in Schizophrenia. Entropy 2024, 26: 545. PMID: 39056908, PMCID: PMC11275472, DOI: 10.3390/e26070545.Peer-Reviewed Original ResearchSubjective trajectoriesBrain connectivity measuresPatient’s brain functionCognitive performancePsychiatric diseasesCourse of developmentBrain functionInformation theoryCortical hierarchyInformation processingConnectivity measuresSchizophreniaHealthy controlsDynamical systems theoryFunctional imagingTransit alterationsTransitionConnectivity statesPerspective of dynamical systemsStateTheoryEntropy generationDynamical systemsDynamicsNeuroimagingStructural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
Male A, Goudzwaard E, Nakahara S, Turner J, Calhoun V, Mueller B, Lim K, Bustillo J, Belger A, Voyvodic J, O'Leary D, Mathalon D, Ford J, Potkin S, Preda A, van Erp T. Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity. Psychiatry Research Neuroimaging 2024, 342: 111843. PMID: 38896909, DOI: 10.1016/j.pscychresns.2024.111843.Peer-Reviewed Original ResearchConceptsSymptom severityFractional anisotropyDiffusion tensor imagingNeurocognitive performanceCognitive performanceAssociated with speed of processingLeft inferior fronto-occipital fasciculusWM abnormalitiesAssociated with neurocognitive performancePathophysiology of schizophreniaCognitive performance deficitsInferior fronto-occipital fasciculusSpeed of processingStructural white matter abnormalitiesMean diffusivityAxial diffusivityFronto-occipital fasciculusHealthy controlsRadial diffusivityRegional WM abnormalitiesNegative symptomsPerformance deficitsWhite matterWhite matter abnormalitiesAssociated with speed
2023
Auditory oddball hypoactivation in schizophrenia
Nakahara S, Male A, Turner J, Calhoun V, Lim K, Mueller B, Bustillo J, O'Leary D, Voyvodic J, Belger A, Preda A, Mathalon D, Ford J, Guffanti G, Macciardi F, Potkin S, Van Erp T. Auditory oddball hypoactivation in schizophrenia. Psychiatry Research Neuroimaging 2023, 335: 111710. PMID: 37690161, DOI: 10.1016/j.pscychresns.2023.111710.Peer-Reviewed Original ResearchConceptsSchizophrenia polygenic risk scoresFunctional magnetic resonance imagingPolygenic risk scoresCognitive performanceOddball targetsAssociated with cognitive performanceRight supramarginal cortexCognitive domain performanceBrain imaging studiesAuditory oddball taskPrecuneus activationSchizophrenia individualsFrontal poleSchizophreniaOddball taskBrain activityRight thalamusHippocampal cortexRegional activityHypoactivationSample 2Sample 1PrecuneusHealthy volunteersCross-sectional data setsEpigenetic associations with adolescent grey matter maturation and cognitive development
Jensen D, Chen J, Turner J, Stephen J, Wang Y, Wilson T, Calhoun V, Liu J. Epigenetic associations with adolescent grey matter maturation and cognitive development. Frontiers In Genetics 2023, 14: 1222619. PMID: 37529779, PMCID: PMC10390095, DOI: 10.3389/fgene.2023.1222619.Peer-Reviewed Original ResearchGM volume increaseGray matter maturationPatterns of brain maturationImprove cognitive performanceGray matterExecutive functionEpisodic memoryCognitive performanceCognitive testsBrain structuresProcessing speedBrain maturationCognitive AssessmentCognitive scoresBrain imagingAged 9BrainEpigenetic associationsAdolescentsLongitudinal cohortDNA methylationHuman neurodevelopmentDNA methylation of genesCytosine-phosphate-guanine (CpG) sitesBrain tissueElevated C-reactive protein mediates the liver-brain axis: a preliminary study
Jiang R, Wu J, Rosenblatt M, Dai W, Rodriguez R, Sui J, Qi S, Liang Q, Xu B, Meng Q, Calhoun V, Scheinost D. Elevated C-reactive protein mediates the liver-brain axis: a preliminary study. EBioMedicine 2023, 93: 104679. PMID: 37356206, PMCID: PMC10320521, DOI: 10.1016/j.ebiom.2023.104679.Peer-Reviewed Original ResearchConceptsRegional gray matter volumeGray matter volumeCognitive functioningMost cognitive measuresUnderlying neurobiological factorsEffect sizeLarge effect sizesProspective memoryVisual memoryCognitive measuresExecutive functionTrail MakingCognitive performanceNeurobiological factorsSmall effect sizesProcessing speedVentral striatumParahippocampal gyrusCognitive declineCognitive impairmentMatter volumeMemoryFunctioningCross-sectional associationsLimited research
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