2025
Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder
Gao H, Sinha R, Wemm S, Milivojevic V. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2025, 49: 619-628. PMID: 39779217, PMCID: PMC11928267, DOI: 10.1111/acer.15529.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment-seeking individualsAlcohol cuesAlcohol cravingResponse to stressPregnenolone groupUse disorderResponse to alcohol cuesGroup x condition interactionHigher alcohol cravingLinear mixed-effects modelsHeart rate variabilityHeart rate variability indicesAutonomic nervous system dysregulationChronic alcohol consumptionRandomized to placeboAutonomic nervous system responsesNervous system dysregulationCravingAlcohol's impactCondition interactionAssociated with autonomic nervous system dysregulationNervous system responsesAutonomic responsesEnhanced autonomic function
2023
Hypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology
Syed S, Sinha R, Milivojevic V, MacDougall A, LaValle H, Angarita G, Fox H. Hypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology. Human Psychopharmacology Clinical And Experimental 2023, 38: e2867. PMID: 37165544, DOI: 10.1002/hup.2867.Peer-Reviewed Original ResearchConceptsAlcohol use disorderRelapse riskDepressive symptomatologyDepressive symptomsAutonomic responsesIndividual relapse riskChronic alcohol useDepressive pathophysiologyAdrenocorticotropic hormoneInhibitory systemPlasma measuresUse disordersClinical practicePhasic changesConsecutive daysAlcohol usePsychological stressStroop performanceDisorder individualsDrinking controlsSymptomatologyImagery exposureCounterbalanced orderSymptomsDepression
2022
Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Milivojevic V, Charron L, Fogelman N, Hermes G, Sinha R. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules 2022, 12: 1593. PMID: 36358943, PMCID: PMC9687893, DOI: 10.3390/biom12111593.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyArousalCocaineCravingFemaleHumansMaleNeurosteroidsPregnenoloneStress, PsychologicalConceptsDiastolic blood pressureCocaine use disorderHeart ratePrecursor pregnenoloneUse disordersCocaine cravingCue-induced cocaine cravingCue-induced anxietyWeeks of treatmentCue-induced cravingAutonomic arousalChronic cocaine usePreg groupBlood pressureDay groupRelapse riskHigher cocainePregnenolone levelsCue-provoked cravingSeparate daysAutonomic responsesCocaine useTreatment-seeking individualsCravingSteroid systems
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