2013
BRG1‐mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling
Chaiyachati BH, Jani A, Wan Y, Huang H, Flavell R, Chi T. BRG1‐mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling. The EMBO Journal 2013, 32: 395-408. PMID: 23321680, PMCID: PMC3567501, DOI: 10.1038/emboj.2012.350.Peer-Reviewed Original ResearchConceptsTreg activationRegulatory T cellsSeverity of inflammationChemokine receptor genesT-cell lineageΑβ T cell lineagesCD4 cellsSuppress autoimmunityProinflammatory roleImmune toleranceFatal inflammationT cellsInflammatory cuesTregsInflammationBrg1 deletionReceptor geneChromatin-remodelling factor BRG1Activation levelsActivationCell lineagesTarget genesATPase activityPoint mutationsCellsA General Approach for Controlling Transcription and Probing Epigenetic Mechanisms: Application to the Cd4 Locus
Wan M, Kaundal R, Huang H, Zhao J, Yang X, Chaiyachati BH, Li S, Chi T. A General Approach for Controlling Transcription and Probing Epigenetic Mechanisms: Application to the Cd4 Locus. The Journal Of Immunology 2013, 190: 737-747. PMID: 23293358, PMCID: PMC3744393, DOI: 10.4049/jimmunol.1201278.Peer-Reviewed Original Research
2012
LoxP-FRT Trap (LOFT): a simple and flexible system for conventional and reversible gene targeting
Chaiyachati BH, Kaundal RK, Zhao J, Wu J, Flavell R, Chi T. LoxP-FRT Trap (LOFT): a simple and flexible system for conventional and reversible gene targeting. BMC Biology 2012, 10: 96. PMID: 23198860, PMCID: PMC3529186, DOI: 10.1186/1741-7007-10-96.Peer-Reviewed Original Research
2009
Molecular basis of CD4 repression by the Swi/Snf‐like BAF chromatin remodeling complex
Wan M, Zhang J, Lai D, Jani A, Prestone‐Hurlburt P, Zhao L, Ramachandran A, Schnitzler GR, Chi T. Molecular basis of CD4 repression by the Swi/Snf‐like BAF chromatin remodeling complex. European Journal Of Immunology 2009, 39: 580-588. PMID: 19180471, PMCID: PMC2774848, DOI: 10.1002/eji.200838909.Peer-Reviewed Original ResearchConceptsCD4 repressionCD4 silencerDominant negative mutantBAF complexNegative mutantSWI/SNF-like BAF chromatinBRG1/BRM-associated factor (BAF) chromatinCD4 silencer functionLinker histone H1Factor (BAF) chromatinT cell developmentKey repressorBAF chromatinSilencer functionBAF57Histone H1ChromatinMolecular basisFlanking regionsRepressionTranslational frameCD4 transcriptionSilencerEarly thymocytesMutants