2025
Lipid Dynamics at Membrane Contact Sites
Reinisch K, De Camilli P, Melia T. Lipid Dynamics at Membrane Contact Sites. Annual Review Of Biochemistry 2025, 94: 479-502. PMID: 40067957, DOI: 10.1146/annurev-biochem-083024-122821.Peer-Reviewed Original ResearchConceptsContact sitesOrganelle contact sitesMembrane contact sitesIntegral membrane proteinsLipid transfer proteinsVesicular traffickingEndoplasmic reticulumLipid transferMembrane proteinsLipid movementOrganellesLipid transportTransfer proteinCellular membranesProteinBilayer asymmetryLipid dynamicsShedding new lightLipidMembranePhysiological mechanismsEukaryotesSitesReticulumTrafficking
2019
Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2
Kargbo-Hill SE, Kauffman KJ, Krout M, Richmond JE, Melia TJ, ColĂłn-Ramos DA. Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2. Developmental Cell 2019, 49: 251-266.e8. PMID: 30880001, PMCID: PMC6482087, DOI: 10.1016/j.devcel.2019.02.013.Peer-Reviewed Original ResearchConceptsGenetic screenForward genetic screenClearance of autophagosomesProtease isoformsAutophagosomesCell bodiesAutophagosome clearanceSynaptic materialNeurodegenerative diseasesMaturationRetrograde transportNeuronal activityAbnormal accumulationNeuronsSingle neuronsClearanceGABARAPVivoTraffickingAutophagyScreenIsoformsMechanismMembraneSynapse
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