A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope
Mannino P, Perun A, Surovtsev I, Ader N, Shao L, Rodriguez E, Melia T, King M, Lusk C. A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope. Nature Cell Biology 2025, 27: 464-476. PMID: 39920277, PMCID: PMC11908896, DOI: 10.1038/s41556-025-01612-1.Peer-Reviewed Original ResearchConceptsInner nuclear membraneDynamin-like protein 1Membrane fissionNuclear envelopeMembrane fission stepNon-canonical rolesDouble-membrane vesiclesProtein 1Nuclear envelope remodelingLattice light-sheet microscopyFission stepDnm1Nuclear autophagyIntact nucleiPerinuclear spaceNuclear membraneAutophagic mechanismsNucleophagyCorrelative lightLight-sheet microscopyFissionElectron tomographyVesiclesVacuolesAtg11
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