The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation
Kyriakides TR, Foster MJ, Keeney GE, Tsai A, Giachelli CM, Clark-Lewis I, Rollins BJ, Bornstein P. The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation. American Journal Of Pathology 2004, 165: 2157-2166. PMID: 15579457, PMCID: PMC1618731, DOI: 10.1016/s0002-9440(10)63265-8.Peer-Reviewed Original ResearchConceptsForeign body giant cellsForeign body reactionCC chemokine ligand 2CCL2-null miceChemokine ligand 2CC chemokine ligandBlood-borne monocytesPeripheral blood monocytesWild-type miceCCL2/MCP1Chemokine ligandGiant cell formationMonocyte recruitmentBlood monocytesFBGC formationMacrophage fusionGiant cellsImplantation sitesBody reactionForeign body giant cell formationMiceInhibitory peptidesCCL2 functionMonocytesChemotactic signals