2019
The impact of modulating the blood–brain barrier on the electrophysiological and histological outcomes of intracortical electrodes
Falcone JD, Sohal H, Kyriakides T, Bellamkonda RV. The impact of modulating the blood–brain barrier on the electrophysiological and histological outcomes of intracortical electrodes. Journal Of Neural Engineering 2019, 16: 046005. PMID: 31048574, DOI: 10.1088/1741-2552/ab1ef9.Peer-Reviewed Original ResearchConceptsCCL2/CCR2 pathwayCCR2 pathwayBlood-brain barrier integrityIntracortical electrodesPro-inflammatory monocytesBlood-brain barrierBBB breachFunctional electrophysiologyChronic outcomesHistological outcomesWeek cohortCCR2 antagonistHistological effectsTreatment groupsElectrode implantationNeurodegenerative modelsBarrier integrityElectrophysiological recordingsNumber of neuronsWeeksHistologyLong-term recordingsBiological mechanismsNeural populationsElectrophysiology
2017
Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix
Kristofik NJ, Qin L, Calabro NE, Dimitrievska S, Li G, Tellides G, Niklason LE, Kyriakides TR. Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix. Biomaterials 2017, 141: 63-73. PMID: 28667900, PMCID: PMC5918415, DOI: 10.1016/j.biomaterials.2017.06.025.Peer-Reviewed Original ResearchConceptsUnmodified graftsVascular graftsCoronary bypass proceduresMechanical propertiesMural cell recruitmentBypass proceduresRat aortaMMP levelsCell recruitmentDecreased failure rateGraftPlatelet studiesGraft mechanical propertiesNative vesselsShelf vascular graftsSmall-diameter vascular graftsTime pointsExtracellular matrixDiameter vascular graftsTensile strengthYoung's modulusWT cellsPresent studySuture retentionFailure rate
1995
Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo
Hugo C, Pichler R, Meek R, Gordon K, Kyriakides T, Floege J, Bornstein P, Couser W, Johnson R. Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo. Kidney International 1995, 48: 1846-1856. PMID: 8587244, DOI: 10.1038/ki.1995.483.Peer-Reviewed Original ResearchConceptsAnti-Thy1 antibodyMesangial cell proliferationThrombospondin-1 expressionMesangial cellsThrombospondin-1Anti-Thy1 nephritisCell proliferationAnti-bFGF antibodyExperimental mesangial proliferative nephritisDe novo expressionMesangial proliferative nephritisGlomerular diseaseNormal ratsProliferative nephritisThrombospondin-1 mRNANovo expressionDouble labelingRatsPDGFAntibodiesNephritisBFGFInfusionDiseaseVivo