2020
The role of extracellular matrix in the pathophysiology of diabetic wounds
Huang Y, Kyriakides TR. The role of extracellular matrix in the pathophysiology of diabetic wounds. Matrix Biology Plus 2020, 6: 100037. PMID: 33543031, PMCID: PMC7852307, DOI: 10.1016/j.mbplus.2020.100037.Peer-Reviewed Original ResearchECM-modifying enzymesExtracellular matrix productionDevelopment of ECMDiabetic woundsStructural proteinsECM moleculesKey ECM moleculesExtracellular matrixMatricellular proteinDiabetes-induced changesMatrix productionImpaired wound healingUlcerated woundsNew insightsProteinImpaired healingTissue dysfunctionTherapeutic strategiesWound healingWoundsHealingEnzyme
1999
Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene
Kyriakides T, Tam J, Bornstein P. Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene. Journal Of Investigative Dermatology 1999, 113: 782-787. PMID: 10571734, DOI: 10.1046/j.1523-1747.1999.00755.x.Peer-Reviewed Original ResearchConceptsGranulation tissueThrombospondin-2Late woundsControl woundsWound healingExtent of angiogenesisRe-epithelization rateAbnormal collagen fibrilsVascular densityLess scarringRete pegsHistologic analysisExcisional woundsControl epitheliumSuch woundsThrombospondin 2 geneTotal cellular contentAccelerated wound healingElevated levelsHealing processMiceWoundsBiopsy punchEarly woundsHealing