Design of “Smart” polymers that can direct intracellular drug delivery
Hoffman A, Stayton P, Press O, Murthy N, Lackey C, Cheung C, Black F, Campbell J, Fausto N, Kyriakides T, Bornstein P. Design of “Smart” polymers that can direct intracellular drug delivery. Polymers For Advanced Technologies 2002, 13: 992-999. DOI: 10.1002/pat.232.Peer-Reviewed Original ResearchPH-sensitive polymerTypes of polymersEndosomal escapeBiomolecular drugsSynthetic polymersPolymeric biomaterialsBiological moleculesPeptide unitsPolymersBiomimetic propertiesEnvironmental signalsEndosomal membranesIntracellular traffickingMolecular mechanismsProtein coatGenetic materialBiological systemsEndosomesViral coatBondsAcidic pHSpecific peptidesInteresting modelLysosomal enzymesTrafficking