2021
Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis
Kwon HK, Lee I, Yu KE, Cahill SV, Alder KD, Lee S, Dussik CM, Back J, Choi J, Song L, Kyriakides TR, Lee FY. Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis. Science Advances 2021, 7: eabf2665. PMID: 34172438, PMCID: PMC8232912, DOI: 10.1126/sciadv.abf2665.Peer-Reviewed Original ResearchConceptsIntra-articular inflammationSeptic arthritisBacterial infectionsDual therapeutic targetingKnee septic arthritisPromising new therapeutic strategyArticular cartilageChallenging clinical problemNovel treatment modalitiesIntracellular bacteriaNew therapeutic strategiesAdjuvant targetingTreatment modalitiesBacterial eradicationSuccessful treatmentHost inflammationCausative bacteriaMurine modelTherapeutic strategiesArthritisTherapeutic goalsClinical problemTherapeutic targetingInflammationVital organs
2020
The role of extracellular matrix in the pathophysiology of diabetic wounds
Huang Y, Kyriakides TR. The role of extracellular matrix in the pathophysiology of diabetic wounds. Matrix Biology Plus 2020, 6: 100037. PMID: 33543031, PMCID: PMC7852307, DOI: 10.1016/j.mbplus.2020.100037.Peer-Reviewed Original ResearchECM-modifying enzymesExtracellular matrix productionDevelopment of ECMDiabetic woundsStructural proteinsECM moleculesKey ECM moleculesExtracellular matrixMatricellular proteinDiabetes-induced changesMatrix productionImpaired wound healingUlcerated woundsNew insightsProteinImpaired healingTissue dysfunctionTherapeutic strategiesWound healingWoundsHealingEnzyme