2019
Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes
Kunkemoeller B, Bancroft T, Xing H, Morris AH, Luciano AK, Wu J, Fernandez-Hernando C, Kyriakides TR. Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes. Diabetes 2019, 68: 2016-2023. PMID: 31391172, PMCID: PMC6754242, DOI: 10.2337/db18-1001.Peer-Reviewed Original ResearchConceptsThrombospondin-2TSP2 expressionDiabetic control miceWound healingEffects of hyperglycemiaImpaired wound healingUnderlying pathological mechanismsDelayed Wound HealingMajor cellular sourceBlood vessel maturationGranulation tissue formationMajor complicationsDiabetic miceControl miceTreatment strategiesDiabetesPathological mechanismsDiabetic woundsAccelerated reepithelializationCellular sourceHigh glucoseHyperglycemiaMatricellular proteinExpression contributesHexosamine pathway
2018
Elevated Thrombospondin‐2 Contributes to Delayed Wound Healing in Diabetes
Kunkemoeller B, Kyriakides T. Elevated Thrombospondin‐2 Contributes to Delayed Wound Healing in Diabetes. The FASEB Journal 2018, 32: 414.3-414.3. DOI: 10.1096/fasebj.2018.32.1_supplement.414.3.Peer-Reviewed Original ResearchKO mice exhibitThrombospondin-2TSP2 expressionDiabetes patientsImpaired healingMouse modelWound healingMice exhibitDb/db miceWild-type miceKO mouse modelUnderlying pathological mechanismsImpaired wound healingDelayed Wound HealingFull-text articlesMajor complicationsDiabetes complicationsDb miceKO miceTreatment strategiesTissue injuryDiabetesPathological mechanismsDiabetic woundsChronic wounds