2024
Targeting hypoxia and thrombospondin‐2 in diabetic wound healing
Huang Y, Xing H, Naud S, Kyriakides T. Targeting hypoxia and thrombospondin‐2 in diabetic wound healing. The FASEB Journal 2024, 38: e70091. PMID: 39383062, PMCID: PMC11486302, DOI: 10.1096/fj.202302429rrr.Peer-Reviewed Original ResearchConceptsThrombospondin-2Diabetic miceWound healingHIF-1aMatricellular protein thrombospondin-2Diabetic woundsImpaired wound healingWounds of diabetic miceDimethyloxalylglycine treatmentTargeting hypoxiaSustained hypoxiaDiabetic patientsTSP2 expressionCell dysfunctionIncreased neovascularizationDiabetic wound healingGenetic ablationDiabetic fibroblastsElevated glucoseReduced hypoxiaImprove healingImmunofluorescence analysisHIF-1a activationHypoxiaWestern blotting
1998
The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult Mice
Kyriakides T, Zhu Y, Yang Z, Bornstein P. The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult Mice. Journal Of Histochemistry & Cytochemistry 1998, 46: 1007-1015. PMID: 9705966, DOI: 10.1177/002215549804600904.Peer-Reviewed Original ResearchConceptsCell-matrix interactionsMatricellular protein thrombospondin-2Adult tissuesThrombospondin-2TSP2-null micePleiotropic phenotypesTissue-forming cellsCell movementEmbryonic developmentDermal fibroblastsPericellular environmentAdhesion defectsDay 15Connective tissueLeidig cellsTissue repairDay 18 embryosDermal cellsCells