2019
Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes
Kunkemoeller B, Bancroft T, Xing H, Morris AH, Luciano AK, Wu J, Fernandez-Hernando C, Kyriakides TR. Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes. Diabetes 2019, 68: 2016-2023. PMID: 31391172, PMCID: PMC6754242, DOI: 10.2337/db18-1001.Peer-Reviewed Original ResearchConceptsThrombospondin-2TSP2 expressionDiabetic control miceWound healingEffects of hyperglycemiaImpaired wound healingUnderlying pathological mechanismsDelayed Wound HealingMajor cellular sourceBlood vessel maturationGranulation tissue formationMajor complicationsDiabetic miceControl miceTreatment strategiesDiabetesPathological mechanismsDiabetic woundsAccelerated reepithelializationCellular sourceHigh glucoseHyperglycemiaMatricellular proteinExpression contributesHexosamine pathway
2007
Thrombospondin 2 deficiency influences extracellular matrix assembly leading to increased ischemia‐induced angiogenesis and arteriogenesis
Kyriakides T, Krady M, Zeng J, Skokos E. Thrombospondin 2 deficiency influences extracellular matrix assembly leading to increased ischemia‐induced angiogenesis and arteriogenesis. The FASEB Journal 2007, 21: a529-a529. DOI: 10.1096/fasebj.21.5.a529-a.Peer-Reviewed Original Research