2025
Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review
Barrios N, Riordan W, Garcia-Rivas V, Peltier M, Roberts W, Verplaetse T, Kohler R, Zhou H, Banini B, McKee S, Cosgrove K, Zakiniaeiz Y. Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review. Biology Of Sex Differences 2025, 16: 24. PMID: 40200334, DOI: 10.1186/s13293-025-00706-7.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol-induced dopamine releaseEffects of alcoholSex differencesAlcohol exposureDopamine measurementsMu-opioid receptorsDopamine releaseEffects of sexProgression of alcohol use disorderDopamine D1 receptor availabilityAlcohol use disorder developmentEffects of prenatal alcohol exposureD1 receptor availabilityStriatal dopamine concentrationsAir-exposed controlsAlcohol-exposed animalsMu-opioid receptor activationPrenatal alcohol exposureDuration of alcohol exposureVentral striatumBrain dopamineReward processingNeurobiological mechanismsReceptor availability
2015
Low-dose prazosin alone and in combination with propranolol or naltrexone: effects on ethanol and sucrose seeking and self-administration in the P rat
Verplaetse T, Czachowski C. Low-dose prazosin alone and in combination with propranolol or naltrexone: effects on ethanol and sucrose seeking and self-administration in the P rat. Psychopharmacology 2015, 232: 2647-2657. PMID: 25743758, PMCID: PMC4504773, DOI: 10.1007/s00213-015-3896-z.Peer-Reviewed Original ResearchConceptsEthanol seekingSucrose seekingSelf-administrationNoradrenergic systemSucrose intakeResponse requirementsDecrease ethanol self-administrationTreat alcohol use disorderSucrose-reinforced behaviorsDecreased ethanol intakeEthanol self-administrationMale alcohol-preferringAlcohol use disorderEthanol reinforcementAlcohol-preferringBehavioral paradigmsEthanol intakeUse disorderDecreased ethanolOral reinforcementProblem drinkersNaltrexoneMedication effectsSeekingTreatment approaches
2012
Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats
Bertholomey M, Verplaetse T, Czachowski C. Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats. Behavioural Brain Research 2012, 238: 252-258. PMID: 23103404, PMCID: PMC3513579, DOI: 10.1016/j.bbr.2012.10.030.Peer-Reviewed Original ResearchConceptsHAD-2 ratsEthanol self-administrationSelf-administrationEthanol seekingP ratsAlcohol-preferring P ratsReinstatement of ethanol seekingIncreased ethanol self-administrationReinstatement of ethanolEthanol's reinforcing effectsBred alcohol-preferringHigh-alcohol-drinkingAlcohol drinkingEffects of yohimbineStress-related changesEthanol reinforcementHAD ratsReinstatement paradigmAlcohol-preferringEthanol drinkingHAD-2Male PPromote relapsePharmacological stressorResponse requirements
2011
Effects of Prazosin, an α1‐Adrenergic Receptor Antagonist, on the Seeking and Intake of Alcohol and Sucrose in Alcohol‐Preferring (P) Rats
Verplaetse T, Rasmussen D, Froehlich J, Czachowski C. Effects of Prazosin, an α1‐Adrenergic Receptor Antagonist, on the Seeking and Intake of Alcohol and Sucrose in Alcohol‐Preferring (P) Rats. Alcohol Clinical And Experimental Research 2011, 36: 881-886. PMID: 21981346, PMCID: PMC3257421, DOI: 10.1111/j.1530-0277.2011.01653.x.Peer-Reviewed Original ResearchConceptsHigh dose of prazosinSucrose-seekingAlcohol-preferringDose of prazosinPharmacologically relevant blood ethanol concentrationsModel of alcohol useLatency to first responseTest daysDecrease alcohol drinkingWeekly extinction sessionsPredisposition to alcohol abuseRats lever-pressedAlcohol-dependent menIncreased response latenciesDecreased alcohol intakeBlood ethanol concentrationReceptor antagonistInitiation of alcoholTesting phaseExtinction sessionsBehavioral sessionA1-adrenergicBred ratsEffects of prazosinHigh doses
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