2025
Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review
Barrios N, Riordan W, Garcia-Rivas V, Peltier M, Roberts W, Verplaetse T, Kohler R, Zhou H, Banini B, McKee S, Cosgrove K, Zakiniaeiz Y. Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review. Biology Of Sex Differences 2025, 16: 24. PMID: 40200334, DOI: 10.1186/s13293-025-00706-7.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol-induced dopamine releaseEffects of alcoholSex differencesAlcohol exposureDopamine measurementsMu-opioid receptorsDopamine releaseEffects of sexProgression of alcohol use disorderDopamine D1 receptor availabilityAlcohol use disorder developmentEffects of prenatal alcohol exposureD1 receptor availabilityStriatal dopamine concentrationsAir-exposed controlsAlcohol-exposed animalsMu-opioid receptor activationPrenatal alcohol exposureDuration of alcohol exposureVentral striatumBrain dopamineReward processingNeurobiological mechanismsReceptor availability
2022
Using machine learning to predict heavy drinking during outpatient alcohol treatment
Roberts W, Zhao Y, Verplaetse T, Moore KE, Peltier MR, Burke C, Zakiniaeiz Y, McKee S. Using machine learning to predict heavy drinking during outpatient alcohol treatment. Alcohol Clinical And Experimental Research 2022, 46: 657-666. PMID: 35420710, PMCID: PMC9180421, DOI: 10.1111/acer.14802.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAlgorithmsEthanolFemaleHumansMachine LearningMaleOutpatientsTreatment OutcomeConceptsAlcohol use disorderHeavy drinkingTreatment outcomesInvasive assessment methodsOutpatient AUD treatmentLast monthOutpatient alcohol treatmentMultisite clinical trialAccurate clinical predictionsHeavy alcohol useSex differencesBi-weekly sessionsAlcohol treatment outcomesPatient characteristicsClinical outcomesClinical trialsClinical dataStratified analysisEffective treatmentPsychiatric disordersUse disordersAUD treatmentSubstantial sex differencesAlcohol treatmentFirst month
2016
An overview of alcohol and tobacco/nicotine interactions in the human laboratory
Verplaetse TL, McKee SA. An overview of alcohol and tobacco/nicotine interactions in the human laboratory. The American Journal Of Drug And Alcohol Abuse 2016, 43: 186-196. PMID: 27439453, PMCID: PMC5588903, DOI: 10.1080/00952990.2016.1189927.Peer-Reviewed Original ResearchConceptsAlcohol-tobacco interactionsNicotine interactionsHuman laboratorySubjective responsesBlood alcohol curveDrinking cuesAlcohol use disorderOverview of alcoholNicotine deprivationSelf-administration behaviorDrugs of abuseAlcohol cravingReciprocal influenceAlcohol curveAlcohol influenceSubjective effectsUse disordersTobacco/nicotineNicotine administrationTobacco useInteractive effectsCravingMajor public health concernPublic health concernDrinkersEffect of Varenicline Combined with High‐Dose Alcohol on Craving, Subjective Intoxication, Perceptual Motor Response, and Executive Cognitive Function in Adults with Alcohol Use Disorders: Preliminary Findings
Verplaetse TL, Pittman BP, Shi JM, Tetrault JM, Coppola S, McKee SA. Effect of Varenicline Combined with High‐Dose Alcohol on Craving, Subjective Intoxication, Perceptual Motor Response, and Executive Cognitive Function in Adults with Alcohol Use Disorders: Preliminary Findings. Alcohol Clinical And Experimental Research 2016, 40: 1567-1576. PMID: 27246567, PMCID: PMC4930423, DOI: 10.1111/acer.13110.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholic IntoxicationAlcohol-Related DisordersAssociation LearningBlood PressureCravingDose-Response Relationship, DrugDouble-Blind MethodEthanolExecutive FunctionFemaleHeart RateHumansMaleMemory, Short-TermNicotinic AgonistsPsychological TestsPsychomotor PerformanceVareniclineYoung AdultConceptsPerceptual-motor functionAlcohol use disorderExecutive cognitive functionCognitive functionDose of alcoholSubjective reactivitySubjective intoxicationHigh-dose alcoholNonalcoholic control beverageAlcohol-motivated behaviorsUse disordersEffects of vareniclineAssociative learningAversive eventsLaboratory paradigmDiastolic blood pressureAlcohol cravingControl beverageMotor responsePhysiologic reactivityAlcohol-related increasesLaboratory sessionsMotor functionBlood pressurePreliminary investigation
2015
Low-dose prazosin alone and in combination with propranolol or naltrexone: effects on ethanol and sucrose seeking and self-administration in the P rat
Verplaetse T, Czachowski C. Low-dose prazosin alone and in combination with propranolol or naltrexone: effects on ethanol and sucrose seeking and self-administration in the P rat. Psychopharmacology 2015, 232: 2647-2657. PMID: 25743758, PMCID: PMC4504773, DOI: 10.1007/s00213-015-3896-z.Peer-Reviewed Original ResearchConceptsEthanol seekingSucrose seekingSelf-administrationNoradrenergic systemSucrose intakeResponse requirementsDecrease ethanol self-administrationTreat alcohol use disorderSucrose-reinforced behaviorsDecreased ethanol intakeEthanol self-administrationMale alcohol-preferringAlcohol use disorderEthanol reinforcementAlcohol-preferringBehavioral paradigmsEthanol intakeUse disorderDecreased ethanolOral reinforcementProblem drinkersNaltrexoneMedication effectsSeekingTreatment approaches
2012
Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats
Bertholomey M, Verplaetse T, Czachowski C. Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats. Behavioural Brain Research 2012, 238: 252-258. PMID: 23103404, PMCID: PMC3513579, DOI: 10.1016/j.bbr.2012.10.030.Peer-Reviewed Original ResearchConceptsHAD-2 ratsEthanol self-administrationSelf-administrationEthanol seekingP ratsAlcohol-preferring P ratsReinstatement of ethanol seekingIncreased ethanol self-administrationReinstatement of ethanolEthanol's reinforcing effectsBred alcohol-preferringHigh-alcohol-drinkingAlcohol drinkingEffects of yohimbineStress-related changesEthanol reinforcementHAD ratsReinstatement paradigmAlcohol-preferringEthanol drinkingHAD-2Male PPromote relapsePharmacological stressorResponse requirements
2011
Effects of Prazosin, an α1‐Adrenergic Receptor Antagonist, on the Seeking and Intake of Alcohol and Sucrose in Alcohol‐Preferring (P) Rats
Verplaetse T, Rasmussen D, Froehlich J, Czachowski C. Effects of Prazosin, an α1‐Adrenergic Receptor Antagonist, on the Seeking and Intake of Alcohol and Sucrose in Alcohol‐Preferring (P) Rats. Alcohol Clinical And Experimental Research 2011, 36: 881-886. PMID: 21981346, PMCID: PMC3257421, DOI: 10.1111/j.1530-0277.2011.01653.x.Peer-Reviewed Original ResearchConceptsHigh dose of prazosinSucrose-seekingAlcohol-preferringDose of prazosinPharmacologically relevant blood ethanol concentrationsModel of alcohol useLatency to first responseTest daysDecrease alcohol drinkingWeekly extinction sessionsPredisposition to alcohol abuseRats lever-pressedAlcohol-dependent menIncreased response latenciesDecreased alcohol intakeBlood ethanol concentrationReceptor antagonistInitiation of alcoholTesting phaseExtinction sessionsBehavioral sessionA1-adrenergicBred ratsEffects of prazosinHigh doses
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