2022
Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Roberts W, Verplaetse T, Burke C, Morris E, McKee S, Cosgrove K. Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes. Nicotine & Tobacco Research 2022, 25: 1047-1051. PMID: 36107715, PMCID: PMC10077933, DOI: 10.1093/ntr/ntac215.Peer-Reviewed Original ResearchMeSH KeywordsAmphetamineCigarette SmokingDopamineFemaleHumansMalePositron-Emission TomographyPrefrontal CortexVerbal LearningConceptsCognitive functionVerbal learningPrefrontal cortexCognitive deficitsWorse verbal learningBrain-behavior relationshipsD2R availabilityDorsolateral prefrontal cortexCognitive performanceComputerized testsTask performanceCogState batteryInhibitory controlNeurocognitive testsReceptor availabilityMesocortical dopaminePositron emission tomographyDopamine D2/3 receptor availabilityMemoryCognitionD2/3 receptor availabilityDopamine releaseSmoking variablesSubject samplesDeficits
2020
Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study
Verplaetse TL, Peltier MR, Roberts W, Moore KE, Pittman BP, McKee SA. Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study. Nicotine & Tobacco Research 2020, 22: 1316-1321. PMID: 32152625, PMCID: PMC7364844, DOI: 10.1093/ntr/ntaa022.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioFaster nicotine metabolismHigher nicotine metabolite ratioE-cigarette useCigarette smoking statusSlower nicotine metabolismNicotine metabolismE-cigarettesSmoking statusCigarette smokingMetabolite ratiosE-cigarette use statusPopulation-based studyLongitudinal cohort studyWave 1Cigarette smoking behaviorCohort studyClinical trialsTobacco usePATH studyHealth StudySmoking behaviorEarly interventionUS populationCombustible cigarettesProspective association of e‐cigarette and cigarette use with alcohol use in two waves of the Population Assessment of Tobacco and Health
Roberts W, Verplaetse T, Peltier MKR, Moore KE, Gueorguieva R, McKee SA. Prospective association of e‐cigarette and cigarette use with alcohol use in two waves of the Population Assessment of Tobacco and Health. Addiction 2020, 115: 1571-1579. PMID: 31977106, PMCID: PMC7340560, DOI: 10.1111/add.14980.Peer-Reviewed Original ResearchConceptsAlcohol use outcomesHazardous alcohol useE-cigarette useE-cigarettesCigarette useAlcohol useUse outcomesExposure groupCigarette usersTotal drinksSocio-demographic risk factorsUnited States adult populationWave 1Non-institutionalized adultsStates adult populationHarmful alcohol consumptionNon-daily useE-cigarette usersPoorer alcohol use outcomesSocio-demographic characteristicsRisk factorsHealth SurveyHigher oddsTobacco cigarettesAlcohol abuse
2018
Intersection of E-Cigarette Use and Gender on Transitions in Cigarette Smoking Status: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health Study
Verplaetse TL, Moore KE, Pittman BP, Roberts W, Oberleitner LM, Peltier M, Hacker R, Cosgrove KP, McKee SA. Intersection of E-Cigarette Use and Gender on Transitions in Cigarette Smoking Status: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health Study. Nicotine & Tobacco Research 2018, 21: 1423-1428. PMID: 30239953, PMCID: PMC6751514, DOI: 10.1093/ntr/nty187.Peer-Reviewed Original ResearchConceptsE-cigarette useE-cigarette usersCigarette smoking statusE-cigarettesSmoking statusSmoking cessationCigarette smokersSmoking relapseGreater riskDaily e-cigarette usersWave 1Stratified analysisHigher oddsHealth StudyPotential riskSmokingRelapseDrug AdministrationElectronic cigarettesSmokersPopulation AssessmentPotential aidMenWomenRiskDeveloping a Laboratory Model of Smoking Lapse Targeting Stress and Brief Nicotine Deprivation
Oberleitner LMS, Moore KE, Verplaetse T, Roberts W, McKee SA. Developing a Laboratory Model of Smoking Lapse Targeting Stress and Brief Nicotine Deprivation. Experimental And Clinical Psychopharmacology 2018, 26: 244-250. PMID: 29863382, PMCID: PMC5990030, DOI: 10.1037/pha0000187.Peer-Reviewed Original ResearchConceptsNicotine deprivationAd libitum smokingSmoking lapse behaviorHuman laboratory modelImagery inductionSmoking periodOnly significant differenceDaily smokersTobacco cravingMonetary reinforcementSmokingSeparate daysHuman laboratoryLapse behaviorSignificant differencesMood statesEffects of stressReduced abilityDelay periodNegative mood statesPrimary aimStress imagerySecondary goalCurrent studyNeutral imageryPilot investigation of the effect of carvedilol on stress-precipitated smoking-lapse behavior
Verplaetse TL, Weinberger AH, Ashare RL, Pittman BP, Shi JM, Tetrault JM, Lavery M, McKee SA. Pilot investigation of the effect of carvedilol on stress-precipitated smoking-lapse behavior. Journal Of Psychopharmacology 2018, 32: 1003-1009. PMID: 29692206, PMCID: PMC6258014, DOI: 10.1177/0269881118767647.Peer-Reviewed Original ResearchConceptsEffects of carvedilolSmoking lapse behaviorAdrenergic antagonistsTobacco cravingSmoking outcomesPhysiologic reactivitySystolic blood pressureNumber of cigarettesNicotine-motivated behaviors× time effectSelf-administration periodEffects of α1Human laboratory modelNicotine-deprived smokersPlacebo groupBlood pressureAdrenergic antagonismMedication conditionClinical indicationsNoradrenergic systemSubsequent smokingHeart rateProperties of drugsSmokingCarvedilol
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