2025
Sex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review
Barrios N, Nartey N, Yue J, Riordan W, Kohler R, Verplaetse T, Roberts W, Carretta R, Banini B, Zhou H, Garcia-Rivas V, Blackford J, Zakiniaeiz Y. Sex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review. Current Addiction Reports 2025, 12: 10. PMID: 40343159, PMCID: PMC12058214, DOI: 10.1007/s40429-025-00624-z.Peer-Reviewed Original ResearchWhite matter tract integrityAlcohol use disorderTract integritySex differencesUse disorderNeurotoxic effects of alcoholAlcohol-related health consequencesExamined sex differencesEffects of alcoholAlcohol use historyWell-characterized sampleDiffusion magnetic resonance imagingEvidence of sex-related differencesNeurobiological mechanismsPsychiatric comorbiditiesSubstance useSystematic reviewSex-related differencesNeurotoxic effectsIndividualized treatment optionsMagnetic resonance imagingDisordersAlcoholGoogle Scholar databasesTreatment options
2024
Imaging a putative marker of brain cortisol regulation in alcohol use disorder
Verplaetse T, Hillmer A, Bhatt S, Rusowicz A, Li S, Nabulsi N, Matuskey D, Huang Y, McKee S, Cosgrove K. Imaging a putative marker of brain cortisol regulation in alcohol use disorder. Neurobiology Of Stress 2024, 29: 100609. PMID: 38304303, PMCID: PMC10832501, DOI: 10.1016/j.ynstr.2024.100609.Peer-Reviewed Original ResearchAlcohol use disorderAnterior cingulate cortexDrinking days/weekModerate to severe alcohol use disorderHealthy controlsHypothalamic-pituitary-adrenal (HPA) axisSevere alcohol use disorderPositron emission tomographyHPA axis dysfunctionHPA axis functionRelease of glucocorticoid hormonesAlcohol consumptionAssociated with drinkingVentromedial PFCCingulate cortexHigh-resolution research tomographHPA activityUse disorderDrinking episodesCortisol regulationAxis functionVmPFCPeripheral cortisolBrain availabilityDisordered background
2015
Low-dose prazosin alone and in combination with propranolol or naltrexone: effects on ethanol and sucrose seeking and self-administration in the P rat
Verplaetse T, Czachowski C. Low-dose prazosin alone and in combination with propranolol or naltrexone: effects on ethanol and sucrose seeking and self-administration in the P rat. Psychopharmacology 2015, 232: 2647-2657. PMID: 25743758, PMCID: PMC4504773, DOI: 10.1007/s00213-015-3896-z.Peer-Reviewed Original ResearchConceptsEthanol seekingSucrose seekingSelf-administrationNoradrenergic systemSucrose intakeResponse requirementsDecrease ethanol self-administrationTreat alcohol use disorderSucrose-reinforced behaviorsDecreased ethanol intakeEthanol self-administrationMale alcohol-preferringAlcohol use disorderEthanol reinforcementAlcohol-preferringBehavioral paradigmsEthanol intakeUse disorderDecreased ethanolOral reinforcementProblem drinkersNaltrexoneMedication effectsSeekingTreatment approaches
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