2023
Sex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Verplaetse T, Roberts W, McKee S, Cosgrove K. Sex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes. Frontiers In Behavioral Neuroscience 2023, 17: 1192740. PMID: 37358969, PMCID: PMC10288103, DOI: 10.3389/fnbeh.2023.1192740.Peer-Reviewed Original ResearchSex steroid hormone levelsSteroid hormone levelsLow estradiol levelsTobacco smokingSex-matched counterpartsHormone levelsFree testosteroneEstradiol levelsAmphetamine administrationR availabilityPositron emission tomography scanPrimary addictive componentEmission tomography scanDopamine D2/3 receptor availabilityEffects of nicotineSex steroid hormonesAge-matched controlsCortical brain regionsD2/3 receptor availabilityNicotinic acetylcholine receptorsSex differencesDorsolateral prefrontal cortexDrug-taking behaviorDopaminergic actionsAddictive component
2018
Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction
Verplaetse T, Morris ED, McKee SA, Cosgrove KP. Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction. Current Opinion In Behavioral Sciences 2018, 23: 196-202. PMID: 31341936, PMCID: PMC6656369, DOI: 10.1016/j.cobeha.2018.04.004.Peer-Reviewed Original ResearchSmoking addictionNicotinic acetylcholine receptor systemReceptor systemNon-nicotine factorsRecent imaging literatureSex differencesNicotine replacement therapyDopamine receptor systemAcetylcholine receptor systemNicotine-motivated behaviorsFuture medication developmentNicotine-related reinforcementTobacco smokingImaging findingsNicotine administrationReplacement therapyDopaminergic systemNeurochemical mechanismsNicotinic acetylcholineDopamine systemMedication developmentLines of evidenceSmokingImaging literatureWomen
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