Featured Publications
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nature Neuroscience 2012, 15: 1245-1254. PMID: 22864611, PMCID: PMC3431440, DOI: 10.1038/nn.3181.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnimalsAntipsychotic AgentsBenzamidesChromatin ImmunoprecipitationClozapineDNA MethylationGenetic VectorsHEK293 CellsHerpesvirus 2, HumanHistone Deacetylase 2HistonesHumansHydroxamic AcidsImmunohistochemistryMiceMice, KnockoutPatch-Clamp TechniquesPlasmidsPrefrontal CortexPromoter Regions, GeneticPyridinesReal-Time Polymerase Chain ReactionReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateReflex, StartleSchizophrenic PsychologyVorinostat
2018
HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice
de la Fuente Revenga M, Ibi D, Saunders J, Cuddy T, Ijaz M, Toneatti R, Kurita M, Holloway T, Shen L, Seto J, Dozmorov M, González-Maeso J. HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice. Neuroscience 2018, 388: 102-117. PMID: 30025863, PMCID: PMC6129430, DOI: 10.1016/j.neuroscience.2018.07.010.Peer-Reviewed Original ResearchConceptsHDAC inhibitor SAHAChronic treatmentControl miceFrontal cortexSchizophrenia patientsSynaptic plasticityChronic antipsychotic drug exposureHistone deacetylase 2 (HDAC2) expressionGlutamatergic pyramidal neuronsChronic antipsychotic treatmentAntipsychotic drug exposureAntipsychotic drug actionNew therapeutic approachesConditional knockout micePlasticity-related genesAntipsychotic treatmentPyramidal neuronsDrug exposureAntipsychotic drugsFunctional synapsesHDAC2 functionTherapeutic approachesKnockout micePresynaptic terminalsSAHA treatment
2013
Chronic treatment with LY341495 decreases 5-HT2A receptor binding and hallucinogenic effects of LSD in mice
Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J. Chronic treatment with LY341495 decreases 5-HT2A receptor binding and hallucinogenic effects of LSD in mice. Neuroscience Letters 2013, 536: 69-73. PMID: 23333599, PMCID: PMC3578056, DOI: 10.1016/j.neulet.2012.12.053.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsDrug AntagonismEarly Growth Response Protein 1Early Growth Response Protein 2HallucinogensLysergic Acid DiethylamideMaleMiceMice, KnockoutProto-Oncogene Proteins c-fosRadioligand AssayReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSomatosensory CortexStereotyped BehaviorXanthenesConceptsLysergic acid diethylamideChronic treatmentHallucinogenic drugsHallucinogenic effectsHead-twitch behaviorHallucinogenic 5MGlu2 receptorLast injectionSomatosensory cortexLY341495Serotonin 5Receptor bindingAcid diethylamideC-fosReceptor ligandsMiceDrugsTreatmentEgr-2Egr-1ReceptorsBehavioral responsesKnockoutHigh affinityMetabotropic
2012
Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice
Moreno JL, Holloway T, Umali A, Rayannavar V, Sealfon SC, González-Maeso J. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology 2012, 225: 217-226. PMID: 22842765, PMCID: PMC3552490, DOI: 10.1007/s00213-012-2809-7.Peer-Reviewed Original ResearchConceptsChronic clozapineLysergic acid diethylamideAtypical antipsychotic drug actionHead-twitch behaviorC-fosAntipsychotic-like activityAntipsychotic drug actionTherapeutic-like effectsMouse somatosensory cortexSchizophrenia-like behavioral alterationsEgr-2Egr-1Chronic haloperidolChronic treatmentClozapine administrationDrug therapyOptimal treatmentSomatosensory cortexSingle administrationAntipsychotic drugsMurine modelMouse modelRodent modelsSerotonin 5Behavioral alterations