2023
3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
Nikolaev Y, Ziolkowski L, Pang S, Li W, Feketa V, Xu C, Gracheva E, Bagriantsev S. 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle. Science Advances 2023, 9: eadi4147. PMID: 37703368, PMCID: PMC10499330, DOI: 10.1126/sciadv.adi4147.Peer-Reviewed Original ResearchHuman TRPV1 structure and inhibition by the analgesic SB-366791
Neuberger A, Oda M, Nikolaev Y, Nadezhdin K, Gracheva E, Bagriantsev S, Sobolevsky A. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nature Communications 2023, 14: 2451. PMID: 37117175, PMCID: PMC10147690, DOI: 10.1038/s41467-023-38162-9.Peer-Reviewed Original ResearchConceptsSB-366791Transient receptor potential (TRP) ion channelsPotential ion channelsPain pathwaysPain therapyPain treatmentPsychiatric disordersOpioid crisisTherapy targetTRPV1 inhibitorElectrophysiological recordingsHuman TRPV1TRP channelsTRPV1New drugsDisease conditionsVanilloid subfamilyIon channelsTreatmentInhibitorsOpioidsPainTherapyDiseaseCryo-electron microscopy structure
2020
Lamellar cells in Pacinian and Meissner corpuscles are touch sensors
Nikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. Science Advances 2020, 6: eabe6393. PMID: 33328243, PMCID: PMC7744075, DOI: 10.1126/sciadv.abe6393.Peer-Reviewed Original ResearchLamellar cellsR-type voltage-gated calcium channelsMeissner corpusclesAction potentialsChannel-dependent action potentialsPacinian corpusclesVoltage-gated calcium channelsSensory afferent neuronsNon-neuronal cellsBill skinAfferent neuronsNeuronal afferentsCalcium channelsElectrophysiological recordingsTactile stimuliCorpusclesIon channelsCellsSkinFirst evidenceTactile organsAfferentsNeuronsPiezo2 Integrates Mechanical and Thermal Cues in Vertebrate Mechanoreceptors
Nikolaev Y, Zheng W, Gracheva E, Bagriantsev S. Piezo2 Integrates Mechanical and Thermal Cues in Vertebrate Mechanoreceptors. Biophysical Journal 2020, 118: 396a. DOI: 10.1016/j.bpj.2019.11.2254.Peer-Reviewed Original ResearchCNGA3 acts as a cold sensor in hypothalamic neurons
Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO. CNGA3 acts as a cold sensor in hypothalamic neurons. ELife 2020, 9: e55370. PMID: 32270761, PMCID: PMC7182431, DOI: 10.7554/elife.55370.Peer-Reviewed Original Research
2019
Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors
Zheng W, Nikolaev YA, Gracheva EO, Bagriantsev SN. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 17547-17555. PMID: 31413193, PMCID: PMC6717272, DOI: 10.1073/pnas.1910213116.Peer-Reviewed Original ResearchA Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds. Cell Reports 2019, 26: 1979-1987.e3. PMID: 30784581, PMCID: PMC6420409, DOI: 10.1016/j.celrep.2019.01.100.Peer-Reviewed Original ResearchConceptsTrigeminal ganglionPiezo2 ion channelsExpression of moleculesExpression of factorsPiezo2 expressionSomatosensory neuronsNeuronal subtypesSomatosensory systemSuch neuronsSpecialist birdsBird speciesMolecular variationFamily AnatidaeForaging behaviorTactile specializationNeuronsMechanoreceptorsSpecies analysisGangliaGeneral roleBehavioral phenotypesIon channelsGeneral mechanismTactile specialistsFunction of mechanoreceptors
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