2003
Molecular determinants of ligand interaction with the capsaicin receptor
Jordt S, Julius D. Molecular determinants of ligand interaction with the capsaicin receptor. Journal Of Neurochemistry 2003, 85: 4-4. DOI: 10.1046/j.1471-4159.85.s2.4_3.x.Peer-Reviewed Original ResearchReceptor homologPutative transmembrane regionsTransmembrane regionChemical modification studiesChimeric analysisPlasma membraneReceptor orthologsTransmembrane moietyStructural domainsMolecular determinantsChemical labelingIntracellular sideLigand binding assaysStructural determinantsLigand interactionsHomologPain-producing effectsBinding assaysModification studiesEndogenous ligandCapsaicin receptorReceptorsOrthologsMutagenesisBirds
1997
Molecular dissection of gating in the ClC‐2 chloride channel
Jordt S, Jentsch T. Molecular dissection of gating in the ClC‐2 chloride channel. The EMBO Journal 1997, 16: 1582-1592. PMID: 9130703, PMCID: PMC1169762, DOI: 10.1093/emboj/16.7.1582.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell MembraneChloride ChannelsConsensus SequenceHydrogen-Ion ConcentrationIon Channel GatingMembrane PotentialsModels, StructuralMolecular Sequence DataMutagenesis, Site-DirectedOocytesPatch-Clamp TechniquesPoint MutationProtein Structure, SecondaryRatsRecombinant Fusion ProteinsXenopus laevisConceptsChloride channelsClC-2 chloride channelSite-directed mutagenesisMolecular dissectionEquivalent mutationCytoplasmic loopMode of activationClC-0ClC-2Gating mechanismInactivation domainMutationsCell swellingActivationNeuronal excitabilityMutagenesisTransmembraneCell volumeDeletionRegulationPathwayFinal pathwayMechanismVoltage dependenceOutward rectification