2024
Scavenger Receptor CD36 in Tumor-Associated Macrophages Promotes Cancer Progression by Dampening Type I Interferon Signaling.
Xu Z, Kuhlmann-Hogan A, Xu S, Tseng H, Chen D, Tan S, Sun M, Tripple V, Bosenberg M, Miller-Jensen K, Kaech S. Scavenger Receptor CD36 in Tumor-Associated Macrophages Promotes Cancer Progression by Dampening Type I Interferon Signaling. Cancer Research 2024 PMID: 39546763, DOI: 10.1158/0008-5472.can-23-4027.Peer-Reviewed Original ResearchTumor-associated macrophagesIFN-ITumor microenvironmentTumor growthHeterogeneous population of myeloid cellsPharmacological inhibition of CD36Population of myeloid cellsTumor cell quiescenceAnti-tumor immunityDelayed tumor growthTumor inflammatory microenvironmentElevated type I interferonReduced tumor growthMyeloid-specific deletionDeletion of CD36Type I interferon signalingInhibition of CD36Promote cancer progressionI interferon signalingIFN-I responseIFN-I signalingType I interferonScavenger receptor CD36TAM functionNatural suppressor
2020
The role of CD36 in macrophage lipid metabolism and function in tumor microenvironment
Xu Z, Xu S, Kuhlmann A, Kaech S. The role of CD36 in macrophage lipid metabolism and function in tumor microenvironment. The Journal Of Immunology 2020, 204: 240.9-240.9. DOI: 10.4049/jimmunol.204.supp.240.9.Peer-Reviewed Original ResearchTumor-associated macrophagesTumor microenvironmentPhenotype of tumor-associated macrophagesTumor-infiltrating immune populationsExpression of PD-L1Function of tumor-associated macrophagesExpression of scavenger receptor CD36Pro-tumor phenotypeLevels of F4/80Mouse melanoma modelMyeloid-specific deficiencyAnti-tumor functionPro-tumor functionsLipid metabolic phenotypesLipid metabolismSingle-cell RNA sequencingExpression of CD36Scavenger receptor CD36TAM subsetsPD-L1Immunosuppressive phenotypeUptake of oxLDLMacrophage lipid metabolismMelanoma modelUptake of oxidized LDL