The role of CD36 in macrophage lipid metabolism and function in tumor microenvironment
Xu Z, Xu S, Kuhlmann A, Kaech S. The role of CD36 in macrophage lipid metabolism and function in tumor microenvironment. The Journal Of Immunology 2020, 204: 240.9-240.9. DOI: 10.4049/jimmunol.204.supp.240.9.Peer-Reviewed Original ResearchTumor-associated macrophagesTumor microenvironmentPhenotype of tumor-associated macrophagesTumor-infiltrating immune populationsExpression of PD-L1Function of tumor-associated macrophagesExpression of scavenger receptor CD36Pro-tumor phenotypeLevels of F4/80Mouse melanoma modelMyeloid-specific deficiencyAnti-tumor functionPro-tumor functionsLipid metabolic phenotypesLipid metabolismSingle-cell RNA sequencingExpression of CD36Scavenger receptor CD36TAM subsetsPD-L1Immunosuppressive phenotypeUptake of oxLDLMacrophage lipid metabolismMelanoma modelUptake of oxidized LDL