2024
Compartment-specific regulation of NaV1.7 in sensory neurons after acute exposure to TNF-α
Tyagi S, Higerd-Rusli G, Ghovanloo M, Dib-Hajj F, Zhao P, Liu S, Kim D, Shim J, Park K, Waxman S, Choi J, Dib-Hajj S. Compartment-specific regulation of NaV1.7 in sensory neurons after acute exposure to TNF-α. Cell Reports 2024, 43: 113685. PMID: 38261513, PMCID: PMC10947185, DOI: 10.1016/j.celrep.2024.113685.Peer-Reviewed Original ResearchTNF-aSensory neuronsEffect of TNF-aSensory neuron excitabilityTumor necrosis factor-aRegulation of NaV1.7Voltage-gated sodiumPro-inflammatory cytokinesCompartment-specific effectsNeuronal plasma membraneSensitize nociceptorsNeuronal excitabilitySomatic membraneChannel N terminusElectrophysiological recordingsP38 MAPKIon channelsFactor AAcute exposureMolecular determinantsNeuronsAxonal endingsPhospho-acceptor sitesPlasma membraneCompartment-specific regulation
2002
Critical Molecular Determinants of Voltage-Gated Sodium Channel Sensitivity to ÎĽ-Conotoxins GIIIA/B
Cummins T, Aglieco F, Dib-Hajj S. Critical Molecular Determinants of Voltage-Gated Sodium Channel Sensitivity to ÎĽ-Conotoxins GIIIA/B. Molecular Pharmacology 2002, 61: 1192-1201. DOI: 10.1016/s0026-895x(24)12216-x.Peer-Reviewed Original ResearchRat skeletal muscle sodium channelsSodium channel isoformsSkeletal muscle sodium channelMuscle sodium channelsBinding to specific residuesChannel isoformsNeuronal channelsSodium channelsHigh-affinity binding sitesRNav1.4Electrophysiological techniquesExchange of serineNav1.4K substitutionGIIIBDevelopment of toxinsHNav1.4Molecular determinantsPore residuesDifferential sensitivityChannel sensitivityChimera constructs
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