2024
Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids
Trudler D, Ghatak S, Bula M, Parker J, Talantova M, Luevanos M, Labra S, Grabauskas T, Noveral S, Teranaka M, Schahrer E, Dolatabadi N, Bakker C, Lopez K, Sultan A, Patel P, Chan A, Choi Y, Kawaguchi R, Stankiewicz P, Garcia-Bassets I, Kozbial P, Rosenfeld M, Nakanishi N, Geschwind D, Chan S, Lin W, Schork N, Ambasudhan R, Lipton S. Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids. Molecular Psychiatry 2024, 30: 1479-1496. PMID: 39349966, PMCID: PMC11919750, DOI: 10.1038/s41380-024-02761-9.Peer-Reviewed Original ResearchMEF2C haploinsufficiency syndromeLoss-of-function mutationsCerebral organoidsHaploinsufficiency syndromeReceptor antagonistHiPSC-neuronsDecreased neurogenesisSevere formCerebrocortical neuronsAnimal studiesExtrasynaptic activationMEF2CAbnormal phenotypesNeurodevelopmentNeuronsDeficitsOrganoidsTranscription factorsMutationsNitroSynapsinGene networksDysregulation of miRNA expression
2023
Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression
Tse W, Pochwat B, Szewczyk B, Misztak P, Bobula B, Tokarski K, Worch R, Czarnota-Bojarska M, Lipton S, Zaręba-Kozioł M, Bijata M, Wlodarczyk J. Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression. Neuropharmacology 2023, 241: 109729. PMID: 37797736, DOI: 10.1016/j.neuropharm.2023.109729.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexLong-term potentiationChronic restraint stress mouse modelSynaptic plasticityN-methyl-D-aspartate receptor antagonistRestraint stress mouse modelMale C57BL/6J miceAntidepressant-like activityTail suspension testStress mouse modelFunctional synaptic plasticityMajor depressive disorderAntidepressant potentialPharmacological treatmentPsychotomimetic effectsReceptor antagonistC57BL/6J miceDepressive behaviorSucrose preferenceDepressive disorderNitroSynapsinMouse modelSuspension testBehavioral disturbancesCerebrocortical neurons
2001
Potential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging
Le D, Lipton S. Potential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging. Drugs & Aging 2001, 18: 717-724. PMID: 11735619, DOI: 10.2165/00002512-200118100-00001.Peer-Reviewed Original ResearchConceptsReceptor antagonistN-methyl-D-aspartate receptor antagonistN-methyl-D-aspartate (NMDA) receptor complexSafe NMDA antagonistMultiple clinical trialsNMDA receptor antagonistChronic painClinical trialsNMDA antagonistsGlutamate receptorsParkinson's diseaseNeurological disordersNeurodegenerative diseasesDiseaseAdverse effectsAntagonistReceptor complexCurrent useDrugsAdequate levelPainMemantineDysfunctionNitroglycerinStroke
1997
Molecular basis of glutamate toxicity in retinal ganglion cells
Sucher N, Lipton S, Dreyer E. Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Research 1997, 37: 3483-3493. PMID: 9425525, DOI: 10.1016/s0042-6989(97)00047-3.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsExcitatory amino acidsNMDA receptor antagonistRetinal ischemiaReceptor antagonistGanglion cellsGlutamate toxicityAnterior ischemic optic neuropathyN-methyl-D-aspartate (NMDA) subtypeNMDA receptor-mediated toxicityNon-NMDA receptor subtypesAcute vascular insultCentral artery occlusionOptic nerve traumaIschemic optic neuropathyGlutamate-induced neurotoxicitySelective NMDA receptor antagonistGlutamate-induced depolarizationVoltage-gated Ca2Amino acid glutamateOptic neuritisNerve traumaArtery occlusionFuture clinical useNeuronal loss
1996
Cytoskeletal Breakdown and Apoptosis Elicited by NO Donors in Cerebellar Granule Cells Require NMDA Receptor Activation
Bonfoco E, Leist M, Zhivotovsky B, Orrenius S, Lipton S, Nicotera P. Cytoskeletal Breakdown and Apoptosis Elicited by NO Donors in Cerebellar Granule Cells Require NMDA Receptor Activation. Journal Of Neurochemistry 1996, 67: 2484-2493. PMID: 8931482, DOI: 10.1046/j.1471-4159.1996.67062484.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAstrocytesCalciumCells, CulturedCerebellumCysteineCytoskeletonDizocilpine MaleateDNA FragmentationEnzyme InhibitorsExcitatory Amino Acid AntagonistsNitric OxidePenicillaminePotassiumRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateS-Nitroso-N-AcetylpenicillamineS-NitrosothiolsSignal TransductionTyrosineConceptsCultured cerebellar granule cellsNMDA receptor activationCerebellar granule cellsCytoskeletal breakdownGranule cellsReceptor activationUncompetitive NMDA receptor antagonistsD-aminophosphonovaleric acidNecrosis of neuronsS-nitrosocysteineNO donor S-nitrosocysteineNMDA receptor antagonistNitric oxide donorTyrosine nitrationReceptor antagonistMK-801Astroglial cellsOxide donorIntracellular Ca2NO donorBreakdown of microtubulesCerebellar astroglial cellsApoptosisUnderwent apoptosisCytoskeletal alterations
1993
Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide
Lipton S. Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide. Trends In Neurosciences 1993, 16: 527-532. PMID: 7509524, DOI: 10.1016/0166-2236(93)90198-u.Peer-Reviewed Original ResearchConceptsExcitatory amino acid receptorsAmino acid receptorsAcid receptorsN-methyl-D-aspartate receptorsChronic neurological diseaseNMDA receptor antagonistNMDA receptor activityOpen channel blockOpen channel blockerReceptor antagonistNMDA antagonistsAnimal modelsNeurotoxic damageNeurological diseasesReceptor activityClinical useNitric oxideAntagonistReceptorsAlternative redox statesBlockersDisease
1991
N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro
Sucher N, Aizenman E, Lipton. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. Journal Of Neuroscience 1991, 11: 966-971. PMID: 1672708, PMCID: PMC6575374, DOI: 10.1523/jneurosci.11-04-00966.1991.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsNMDA receptorsGanglion cellsEndogenous GluKA receptorsSpecific NMDA receptor antagonistN-methyl-D-aspartate antagonistsRetinal ganglion cell deathRat retinal ganglion cellsDoses of NMDAGanglion cell deathSpecific NMDA antagonistNMDA receptor antagonistOwn specific receptorsPatch-clamp electrophysiology experimentsAddition of kainateMicroM kainateKainate neurotoxicityReceptor antagonistNMDA antagonistsKainateCellular injuryExogenous glutamateSpecific receptorsDetectable inhibition
1987
Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells
Lipton S, Aizenman E, Loring R. Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells. Pflügers Archiv - European Journal Of Physiology 1987, 410: 37-43. PMID: 3684508, DOI: 10.1007/bf00581893.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsWhole-cell recordingsAcetylcholine responseNicotinic responsesNervous systemMammalian retinal ganglion cellsRat retinal ganglion cellsNicotinic channelsAutonomic ganglion cellsDihydro-β-erythroidineNicotinic receptor antagonistAcetylcholine-induced currentsPeripheral nervous systemNicotinic acetylcholine responsesAgonist-induced currentsCentral nervous systemPatch-clamp techniqueCholinergic responsesReceptor antagonistCentral neuronsToxin FD-tubocurarineNicotinic natureΑ-bungarotoxin
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