2025
diAcCA, a Pro-Drug for Carnosic Acid That Activates the Nrf2 Transcriptional Pathway, Shows Efficacy in the 5xFAD Transgenic Mouse Model of Alzheimer’s Disease
Banerjee P, Wang Y, Carnevale L, Patel P, Raspur C, Tran N, Zhang X, Natarajan R, Roberts A, Baran P, Lipton S. diAcCA, a Pro-Drug for Carnosic Acid That Activates the Nrf2 Transcriptional Pathway, Shows Efficacy in the 5xFAD Transgenic Mouse Model of Alzheimer’s Disease. Antioxidants 2025, 14: 293. PMCID: PMC11939361, DOI: 10.3390/antiox14030293.Peer-Reviewed Original ResearchAlzheimer's diseaseNrf2 transcriptional pathwayTranscriptional pathwaysAmyloid plaque formationMouse model of Alzheimer's diseaseTransgenic mouse model of Alzheimer's diseaseModel of Alzheimer's diseaseAD transgenic miceCorrelated to cognitive declineNeuritic aggregatesTau tanglesAmyloid plaquesPhospho-tauCarnosic acidSynapse lossHuman ADPurified CATransgenic mouse modelPhenolic diterpenesAmyloidMicroglial inflammationPathwayPlaque formationTransgenic miceNrf2
2024
A pro-drug derivative of carnosic acid activates the Nrf2 transcriptional pathway and shows efficacy in Alzheimer’s disease transgenic mice
Banerjee P, Roberts A, Natajarian R, Baran P, Lipton S. A pro-drug derivative of carnosic acid activates the Nrf2 transcriptional pathway and shows efficacy in Alzheimer’s disease transgenic mice. Free Radical Biology And Medicine 2024, 224: s96. DOI: 10.1016/j.freeradbiomed.2024.10.212.Peer-Reviewed Original Research
2022
Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome
Satoh T, Trudler D, Oh C, Lipton S. Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome. Antioxidants 2022, 11: 124. PMID: 35052628, PMCID: PMC8772720, DOI: 10.3390/antiox11010124.Peer-Reviewed Original ResearchSARS-CoV-2 infectionParkinson's diseaseAlzheimer's diseaseNeuroprotective effectsNLRP3 inflammasomeKeap1/Nrf2 transcriptional pathwayCarnosic acidAcute lung diseaseBlood-brain barrierChronic neurodegenerative diseasesNLRP3 inflammasome activationCoronavirus disease 2019Nrf2 transcriptional pathwayNLRP3 inflammasome activityPhase 2 enzyme inductionCOVID-19Potential therapeutic useEndovascular cellsBrain fogCytokine stormLong COVIDLung diseaseBrain parenchymaUnregulated inflammationDisease 2019
2013
Combating Oxidative/Nitrosative Stress with Electrophilic Counterattack Strategies
Satoh T, Akhtar M, Lipton S. Combating Oxidative/Nitrosative Stress with Electrophilic Counterattack Strategies. 2013, 277-307. DOI: 10.1007/978-94-007-5787-5_10.Peer-Reviewed Original ResearchPro-electrophilic drugsKeap1/Nrf2 pathwayTranscription-dependent pathwayCysteine thiol oxidationNitrosative stressOxidative stressStress-induced oxidationHeat shock proteinsRedox regulationSpecific cysteineProlonged oxidative stressNrf2 pathwayPhase 2 enzymesKeap1/Nrf2Redox stressThiol oxidationElectrophilic compoundsDefense systemHerb rosemaryPathwayNormal cellsCarnosic acidNeurodegenerative disordersCounterattack strategiesDeplete glutathione
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