1991
Cryopreservation of postnatal rat retinal ganglion cells: Persistence of voltage- and ligand-gated ionic currents
Sucher N, Cheng T, Lipton S. Cryopreservation of postnatal rat retinal ganglion cells: Persistence of voltage- and ligand-gated ionic currents. Neuroscience 1991, 43: 135-150. PMID: 1717883, DOI: 10.1016/0306-4522(91)90423-l.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsPostnatal rat retinal ganglion cellsOutward currentsRat retinal ganglion cellsCultured retinal ganglion cellsTetraethylammonium-sensitive currentPostnatal retinal ganglion cellsInhibitory amino acidsRetinal cell suspensionsWhole-cell modePatch-clamp techniqueWhole-cell configurationBicuculline methiodideMicroM tetrodotoxinChloride-selective currentsPharmacological sensitivityPotassium currentMicroM Cd2Prolonged time courseAction potentialsProlonged componentsVoltage protocolsSignificant differencesTime course
1986
Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture.
Lipton S. Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 9774-9778. PMID: 3025849, PMCID: PMC387224, DOI: 10.1073/pnas.83.24.9774.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsNatural cell deathElectrical activityDeath of RGCsMammalian retinal ganglion cellsCell deathLevel of activityPostnatal day 2Spontaneous electrical activityElectrical blockadeIntraocular injectionMicroM tetrodotoxinPostnatal weekNeuronal activitySpontaneous activityTrophic factorsPostnatal ratsMammalian retinaDevelopment neuronsDay 2TetrodotoxinBlockadeIndividual neuronsAltered activity