2023
Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial
Rance M, Zhao Z, Zaboski B, Kichuk S, Romaker E, Koller W, Walsh C, Harris-Starling C, Wasylink S, Adams T, Gruner P, Pittenger C, Hampson M. Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial. Psychiatry Research 2023, 328: 115458. PMID: 37722238, PMCID: PMC10695074, DOI: 10.1016/j.psychres.2023.115458.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAnterior prefrontal cortexControl groupDouble-blind clinical trialDouble-blind trialPrimary outcome measureCompulsive disorderHarm/checkingMechanism of actionYale-Brown ObsessiveSecondary outcomesSessions of neurofeedbackActive groupClinical trialsOutcome measuresPrimary symptomsSymptom ScaleObsessive-compulsive symptomsPrefrontal cortexSymptomsTraining protocolGreater reductionSignificant differencesPatientsSham feedback
2021
Transcranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive‐compulsive disorder: Results from two pilot studies
Adams TG, Cisler JM, Kelmendi B, George JR, Kichuk SA, Averill CL, Anticevic A, Abdallah CG, Pittenger C. Transcranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive‐compulsive disorder: Results from two pilot studies. Depression And Anxiety 2021, 39: 37-48. PMID: 34464485, PMCID: PMC8732293, DOI: 10.1002/da.23212.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationMedial prefrontal cortexDefault mode networkObsessive-compulsive disorderDirect current stimulationFunctional connectivityCurrent stimulationSham transcranial direct current stimulationResting-state functional magnetic resonanceSafety learningActive transcranial direct current stimulationEffects of tDCSMainstay of treatmentCommunity volunteersExposure-based psychotherapySuperior frontal gyrusFunctional magnetic resonanceBasal gangliaClinical trialsExposure-based therapyVivo exposureSalience networkSubjective emotional distressAnterior insulaPrefrontal cortex