2025
Early detection of lung injury and matrix metalloproteinase activation in ARDS could improve diagnostic and therapeutic strategies?
Cho S, Jang S, Heerdt P, Thorn S, Sinusas A. Early detection of lung injury and matrix metalloproteinase activation in ARDS could improve diagnostic and therapeutic strategies? Expert Review Of Respiratory Medicine 2025, ahead-of-print: 1-3. PMID: 40462542, DOI: 10.1080/17476348.2025.2515993.Peer-Reviewed Original ResearchUsing Foundation Models as Pseudo-label Generators for Pre-clinical 4D Cardiac CT Segmentation
Rickmann A, Thorn S, Ahn S, Lee S, Uman S, Lysyy T, Burns R, Guerrera N, Spinale F, Burdick J, Sinusas A, Duncan J. Using Foundation Models as Pseudo-label Generators for Pre-clinical 4D Cardiac CT Segmentation. Lecture Notes In Computer Science 2025, 15673: 253-265. DOI: 10.1007/978-3-031-94562-5_23.Peer-Reviewed Original ResearchImage segmentationRobust medical image segmentationAccurate pseudo labelsPseudo-label generationSelf-training strategySelf-training approachMedical image segmentationEnhance segmentation accuracyCardiac image segmentationImprove segmentation qualitySelf-training processPseudo-labelsDomain shiftConsecutive framesCardiac image analysisDeep learningSegmentation qualitySegmentation accuracyModeling tasksIterative updateTemporal inconsistencyMotion trackingCT segmentationHuman datasetsImage analysisRIGHT AND LEFT VENTRICULAR MYOCARDIAL BLOOD FLOW PREDICTS INCIDENT HEART FAILURE AND DEATH IN PERSONS WITH SLEEP DISTURBED BREATHING
Aneni E, Emokpae M, Kapadia S, deKemp R, Beanlands R, Klein R, Yaggi H, Miller E, Veledar E, Thorn S, Sinusas A. RIGHT AND LEFT VENTRICULAR MYOCARDIAL BLOOD FLOW PREDICTS INCIDENT HEART FAILURE AND DEATH IN PERSONS WITH SLEEP DISTURBED BREATHING. Journal Of The American College Of Cardiology 2025, 85: 1479. DOI: 10.1016/s0735-1097(25)01963-1.Peer-Reviewed Original ResearchIncreasing angular sampling for dedicated cardiac SPECT scanner: Implementation with Deep Learning and Validation with human data
Xie H, Alashi A, Thorn S, Chen X, Zhou B, Sinusas A, Liu C. Increasing angular sampling for dedicated cardiac SPECT scanner: Implementation with Deep Learning and Validation with human data. Journal Of Nuclear Cardiology 2025, 102168. PMID: 39986346, DOI: 10.1016/j.nuclcard.2025.102168.Peer-Reviewed Original ResearchLower Extremity Flow Quantification Using Dynamic 82Rb PET: a Preclinical Investigation
Guo L, Thorn S, de Rubio Cruz P, Liu Z, Gallezot J, Liu Q, Moulton E, Carson R, Sinusas A, Liu C. Lower Extremity Flow Quantification Using Dynamic 82Rb PET: a Preclinical Investigation. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, PP: 1-1. DOI: 10.1109/trpms.2025.3542729.Peer-Reviewed Original ResearchImaging Fibroblast Activation Protein Direct Visualization of Matrix Proteolytic Activity in Patients Post Myocardial Infarction
Thorn S, Spinale F, Sinusas A. Imaging Fibroblast Activation Protein Direct Visualization of Matrix Proteolytic Activity in Patients Post Myocardial Infarction. Journal Of The American College Of Cardiology 2025, 85: 592-594. PMID: 39772365, DOI: 10.1016/j.jacc.2024.11.029.Peer-Reviewed Original Research
2024
New horizons in nuclear cardiology: Imaging of peripheral arterial disease
Callegari S, Mena-Hurtado C, Smolderen K, Thorn S, Sinusas A. New horizons in nuclear cardiology: Imaging of peripheral arterial disease. Journal Of Nuclear Cardiology 2024, 46: 102079. PMID: 39549830, DOI: 10.1016/j.nuclcard.2024.102079.Peer-Reviewed Original ResearchPeripheral arterial diseaseDiagnostic modalitiesRisk stratificationArtery diseaseEarly diagnosisImprove risk stratificationAssociated with higher ratesLower extremity peripheral arterial diseaseEvaluation of therapyClinically relevant areasPreclinical modelsObstructive atherosclerotic diseaseClinical studiesArtery stenosisMicrovascular diseasePreprocedural assessmentPeripheral vasculaturePET imagingAtherosclerotic diseaseNuclear cardiologyTherapeutic interventionsClinical diseaseDiseaseComplex physiologyPerfusionCoordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging
Jeng G, Chen P, Hsieh M, Liu Z, Langdon J, Ahn S, Staib L, Stendahl J, Thorn S, Sinusas A, Duncan J, O'Donnell M. Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging. IEEE Transactions On Biomedical Engineering 2024, 71: 3312-3323. PMID: 38941195, PMCID: PMC11637688, DOI: 10.1109/tbme.2024.3420220.Peer-Reviewed Original ResearchPrincipal stretchesAxial displacement componentsSpeckle tracking methodSpeckle tracking approachTracking methodRobust filterDisplacement componentsTissue incompressibilityDisplacement estimationStrain componentsDisplacement gradientsStrain informationLocalized diseased regionStrain imagingLagrangian strainLeast-squares methodTracking approachTracking frameworkCoordinate systemCardiac coordinate systemProbe orientationFilterHigher spatial resolutionCardiac datasetsEnhanced accuracyMolecular Imaging of Fibroblast Activation in Lower Extremity Skeletal Muscles Using a 99mTc-Labeled Inhibitor of Fibroblast Activation Protein in Porcine Model of Peripheral Artery Disease
Jang S, Thorn S, Zohora F, Porcaro O, Burns R, Vermillion B, Callegari S, Guerrera N, DePino A, Liu C, Luna-Gutierrez M, Ferro-Flores G, Sinusas A. Molecular Imaging of Fibroblast Activation in Lower Extremity Skeletal Muscles Using a 99mTc-Labeled Inhibitor of Fibroblast Activation Protein in Porcine Model of Peripheral Artery Disease. Journal Of Nuclear Cardiology 2024, 38: 101997. DOI: 10.1016/j.nuclcard.2024.101997.Peer-Reviewed Original ResearchHybrid SPECT/CT Imaging of Fibroblast Activation Protein Post Myocardial Infarction on Novel 360° CZT Scanner
Thorn S, Burns R, Zohora F, Jang S, Porcaro O, Guerrera N, DePino A, Vermillion B, Liu C, Luna-Gutiérrez M, Ferro-Flores G, Sinusas A. Hybrid SPECT/CT Imaging of Fibroblast Activation Protein Post Myocardial Infarction on Novel 360° CZT Scanner. Journal Of Nuclear Cardiology 2024, 38: 101972. DOI: 10.1016/j.nuclcard.2024.101972.Peer-Reviewed Original ResearchDevelopment Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve.
Vermillion B, Jang S, Alashi A, Burns R, Guerrera N, Depino A, Martins S, Papademetris X, Zeiss C, Guo L, Liu C, Thorn S, Sinusas A. Development Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve. Journal Of Cardiovascular Computed Tomography 2024, 18: s50-s51. DOI: 10.1016/j.jcct.2024.05.117.Peer-Reviewed Original ResearchNon-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome
Jang S, Thorn S, Vermillion B, Alashi A, Zohora F, Lee S, Ahn S, Burns R, Dela Cruz C, Zeiss C, Spinale F, Heerdt P, Sinusas A. Non-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome. Journal Of Cardiovascular Computed Tomography 2024, 18: s46. DOI: 10.1016/j.jcct.2024.05.106.Peer-Reviewed Original ResearchEarly Transient CT Enhancement Post Myocardial Infarction Is Associated With Technetium-99m Pyrophosphate Uptake And Calcium Deposition
Zohora F, Lee S, Lin A, Jang S, Vermillion B, Burns R, Callegari S, DePino A, Guerrera N, Thorn S, Sinusas A. Early Transient CT Enhancement Post Myocardial Infarction Is Associated With Technetium-99m Pyrophosphate Uptake And Calcium Deposition. Journal Of Cardiovascular Computed Tomography 2024, 18: s25-s26. DOI: 10.1016/j.jcct.2024.05.058.Peer-Reviewed Original ResearchComparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation
Alashi A, Vermillion B, Callegari S, Burns R, Guo L, Moulton E, Guerrera N, Depino A, Papademetris X, Zeiss C, Thorn S, Liu C, Sinusas A. Comparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.087. DOI: 10.1093/ehjci/jeae142.087.Peer-Reviewed Original ResearchPeripheral arterial diseaseStandardized uptake valueHindlimb ischemia modelReactive hyperemiaSkeletal muscle perfusionPerfusion reserveCapillary densityPET imagingArtery diseaseNon-ischemicRubidium-82 positron emission tomographyType 2 muscle fibersRelevant pre-clinical modelIndicative of fibrosisManagement of peripheral arterial diseaseCapillary to muscle fiber ratioClinically relevant pre-clinical modelPre-clinical modelsMuscle perfusionFast myosinWeeks post-ligationRb-82 uptakeEvaluate treatment strategiesRabbit hindlimb ischemia modelPositron emission tomographyLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApneaMulti-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography
Ta K, Ahn S, Thorn S, Stendahl J, Zhang X, Langdon J, Staib L, Sinusas A, Duncan J. Multi-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography. IEEE Transactions On Medical Imaging 2024, 43: 2010-2020. PMID: 38231820, PMCID: PMC11514714, DOI: 10.1109/tmi.2024.3355383.Peer-Reviewed Original ResearchMulti-task learning networkCross-stitch unitsComposite loss functionAccurate motion estimationTask-specific networksMotion estimationSegmentation masksLearning networkLoss functionSegmentation stepEchocardiography datasetNetworkMotion displacementMotion analysisMultiple time framesTaskAnalysis pipelineSegmentsStrain measurementsDatasetRepresentationASSESSING VASCULAR FLOW IN ACUTE AND CHRONIC RABBIT MODELS OF HINDLIMB ISCHEMIA USING HIGH-RESOLUTION 2D ANGIOGRAPHY: IMPLICATIONS FOR PET FLOW QUANTIFICATION
Callegari S, Vermillion B, Alashi A, Burns R, Jang S, Guerrera N, Guo L, Depino A, Zohora F, Smolderen K, Hurtado C, Liu C, Thorn S, Sinusas A. ASSESSING VASCULAR FLOW IN ACUTE AND CHRONIC RABBIT MODELS OF HINDLIMB ISCHEMIA USING HIGH-RESOLUTION 2D ANGIOGRAPHY: IMPLICATIONS FOR PET FLOW QUANTIFICATION. Journal Of The American College Of Cardiology 2024, 83: 2251. DOI: 10.1016/s0735-1097(24)04241-4.Peer-Reviewed Original ResearchMULTIMODALITY IMAGING GUIDED INTRAMYOCARDIAL DELIVERY OF IMAGEABLE HYDROGEL POST MYOCARDIAL INFARCTION IMPROVES STRAIN ASSOCIATED WITH INTEGRIN ACTIVATION
Melvinsdottir I, Midgett D, Lee S, Chen K, Avendano R, Ahn S, Thorn S, Uman S, Sinusas A. MULTIMODALITY IMAGING GUIDED INTRAMYOCARDIAL DELIVERY OF IMAGEABLE HYDROGEL POST MYOCARDIAL INFARCTION IMPROVES STRAIN ASSOCIATED WITH INTEGRIN ACTIVATION. Journal Of The American College Of Cardiology 2024, 83: 1399. DOI: 10.1016/s0735-1097(24)03389-8.Peer-Reviewed Original Research
2023
The development of a novel endovascular grasper for challenging inferior vena cava filter retrieval
Chaar C, Kostiuk V, Rodriguez P, Kim T, Rathbone D, Ghandour L, Burns R, Thorn S, Sinusas A, Guzman R, Dardik A. The development of a novel endovascular grasper for challenging inferior vena cava filter retrieval. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2023, 12: 101731. PMID: 38081514, PMCID: PMC11523361, DOI: 10.1016/j.jvsv.2023.101731.Peer-Reviewed Original ResearchTransformer-Based Dual-Domain Network for Few-View Dedicated Cardiac SPECT Image Reconstructions
Xie H, Zhou B, Chen X, Guo X, Thorn S, Liu Y, Wang G, Sinusas A, Liu C. Transformer-Based Dual-Domain Network for Few-View Dedicated Cardiac SPECT Image Reconstructions. Lecture Notes In Computer Science 2023, 14229: 163-172. DOI: 10.1007/978-3-031-43999-5_16.Peer-Reviewed Original ResearchDual-domain networkSPECT image reconstructionImage reconstructionDeep learning methodsPrevious baseline methodsCardiac SPECT imagesHigh-quality imagesReconstruction networkIterative reconstruction processView reconstructionBaseline methodsReconstruction outputLearning methodsClinical softwareReconstruction processImaging problemsProjection dataImage qualityNetworkImagesStationary dataSPECT scannerDiagnosis of CVDLimited amountSoftware
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